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The (Re)discovery of a major brain pathway


It was like something out of a mystery movie, a couple of years ago a scientist, looking at dozens of MRI scans of human brains noticed something surprising. A large, fiber pathway that seemed to be part of the network of connections that process visual information showed up on the scans, but the researcher couldn’t find it mentioned in any of the modern-day anatomy textbooks he had.

“It was this massive bundle of fibers, visible in every brain I examined,” said Jason Yeatman.

“It seemed unlikely that I was the first to have noticed this structure; however, as far as I could tell, it was absent from the literature and from all major neuroanatomy textbooks.”

With his colleagues, Yeatman started some detective work to figure out the identity of that large, mysterious fiber bundle.

From that they have just published the paper on their work, the team describes the history and controversy of the elusive brain pathway, explains how modern MRI techniques rediscovered it, and gives analytical tools researchers can use to identify the brain structure – now known as the vertical occipital fasciculus.

The “aha moment” in identifying the pathway came while Yeatman and Kevin Weiner were poring over the yellowed pages of 19th-century brain atlases in the basement of the Stanford Medical Library.

“Kevin found an atlas, written by Carl Wernicke near the turn of the (20th) century, that depicted the vertical occipital fasciculus,” Yeatman said. “The last time that atlas had been checked out was 1912, meaning we were the first to view these images in the last century.”

From there, Yeatman and Weiner, who share lead authorship on the paper, did more library research revealing the possibilities for why the pathway was forgotten:

In an 1881 neuroanatomy atlas, Wernicke, a well-known anatomist who in 1874 discovered “Wernicke’s area,” which is essential for language, wrote about a fiber pathway in a monkey brain he was examining. He called it “senkrechte Occiptalbündel” (translated as vertical occipital bundle). But its vertical orientation contradicted the belief of one of the most renowned neuroanatomists of the era, Theodor Meynert, who asserted that brain connections could only travel in between the front and the back of the brain, not up and down.

The 1880s and 1890s were a fertile time in the neuroanatomy world, but scientists lacked a shared process for naming the brain structures they found. Looking at drawings of the brain from this time period, Yeatman and coauthors saw that the fiber pathway that they were looking for appeared in brain atlases but was called different things, including “Wernicke’s perpendicular fasciculus,” “perpendicular occipital fasciculus of Wernicke,” and “stratum profundum convexitatis.”

“When we started, it was just for our own knowledge and curiosity,” said Weiner.

“But, after a while, we realized that there was an important story to tell that contained a series of missing links that have been buried for so long within this puzzle of historical conversation among many who are considered the founders of the entire neuroscience field.”

The researchers used a type of MRI measure called diffusion-weighted imaging to measure the size of the pathway and see where in the brain it went. Across brain scans taken from 37 subjects, they found that the vertical occipital fasciculus begins in the occipital lobe – the part of the brain’s visual processing system located at the back of the head. From there, the fibers spread out like a sheet, connecting brain regions that are important for seeing objects with other brain regions that coordinate which objects to focus attention upon.

“We believe that signals carried by the VOF play a role in many perceptual processes, from recognizing a friend’s face to rapidly reading a page of text,” said Yeatman, who is now studying brain mechanisms involved in learning to read.

In the paper, the researchers also provide an algorithm that others can use on their own data to find the pathway and measure its properties.

“To support reproducible research, our lab makes a strong effort to share software and data,” said Brian Wandell, senior author of the paper. “We believe this is a powerful way to ensure that our findings can be both checked and used in labs around the world.”

The researchers also hope that the algorithm will enable other researchers to study the pathway, possibly leading to a better understanding of its role in human cognition and in patient populations.

It’s amazing that the work done over one hundred years ago has just now been rediscovered, moreover it is wonderful to think that we have found out even more about the brain and the parts that make it up. It will be interesting to see where the work takes the researchers and what we learn from all they find.

Brian Wandell, Jason Yeatman, & Kevin Weiner (2014). The vertical occipital fasciculus: A century of controversy resolved by in vivo measurements Proceedings of the National Academy of Sciences : 10.1073/pnas.1418503111

2 responses

  1. You are breathtakingly genius. Congratulations for getting The Smithsonian’s attention. I love you.


    November 19, 2014 at 7:11 am

    • Thanks love, I wouldn’t be able to do it without you 🙂


      November 19, 2014 at 9:44 am

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