We're a little crazy, about science!

Posts tagged “neurology

Grant writing!

writing spelled out in letter tiles

It’s time to help write another grant! In this case, it’s one I actually want. One of these days I’ll write a little tutorial on how I like to do my writing, I think it’s a good system, but then again what works for me may not work for you. This one is particularly complicated though so it needs a lot of attention. It’s not that it’s long, it’s because it’s short.

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The grant proposal

Well today one of my grant proposals is due. Technically it’s due tomorrow, but I always try to submit a day early. Why? Well, technical issues, I’m an anxious person, all that good stuff. This was an equipment grant and I did it at the request of my PI, it’s not the grant I want, but it’s a learning experience, or at least that’s how I’m treating it.

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Exoskeleton experiments

Just a few of the exoskeletons we have in the main lab, two of them are self balancing the other two in the shot are not, but they all have different purposes.

Well let’s toss something else into the pile of “things I’m going to talk about, but can’t share the details because we’re working on a publication.” I’ve got yet another new project I’m working on! This is going to be so freaking cool and I’m super excited to start it. So let’s go over some of the details, at least the bits I can talk about. Eventually when all this stuff gets published, I’m going to have a ton to write about.

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More data!

Old wooden treasure chest with strong glow from inside.
Old wooden treasure chest with strong glow from inside.

It was a surprise to me, but I somehow ended up with a new dataset from a single subject. One that, after processing, could be the key to convincing my Co-PI once and for all that we have something real… or it could just be one giant mess, but if we don’t look we may never know.

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Problem solved

Sometimes we don’t need to think outside the box, the box can stay closed for the moment…

Everyone go back to what you were doing, nothing to see here! Yesterday I had an existential crisis, one that could’ve derailed my technique and any hopes I had at introducing something new into the world. With it, my PhD dissertation topic, meaning I would be over two years in and I would need to reevaluate my goals. Let’s talk about what happened!

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A snag

No tears, please. It’s a waste of good suffering.

You know… that’s how it goes sometimes. You’re cruising along and everything looks great then, BAM! Totally derailed. What happened? Turns out I have a problem with my data. Not a problem persay, more like an anomaly, one that throws a rather large wrench into what WAS a perfectly running operation. Things were looking good, but now… I have a doubt.

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A lot of changes!

While EEG caps look super high tech, it’s actually a low-tech solution to an environment full of electrical noise. Each channel is pre-amplified at the source to reduce contamination as the signal travels down the cable. The first active electrodes? Made sometime in the mid 90’s, so a surprisingly new advancement in the history of EEG!

Well if there was any doubt that I write these daily I’m sure yesterday’s brief post explaining my panic helped answer that question. It really was a busy day and that’s not a bad thing. Things are… changing and I can’t tell how they will turn out now, but I’m anxious to see the outcome. How very mysterious! Let’s talk about it.

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Dataset mining

We use heavy equipment to mine our data around these parts…

I did an experiment! That’s old(ish) news, but now I have some data to play with… lots of data. So now I get to do something somewhat enjoyable and that’s try to get cool and interesting stuff to fall out of it. All you have to do is shake it really hard and hope for the best.

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A breakthrough

Oh yeah!

Well… where the hell do I even start? Yesterday was actually a semi-okay day. I mean the world is still on fire, the pandemic is still killing far too many people( but somehow not enough for the people in charge to care), and I mean let’s face it, it feels like the human race is in the death throes. HOWEVER, all that aside, my microscopic insignificant day wasn’t bad… now I’m worried.

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Neuralink: Beyond the hype

The sewing machine like robot that is the linchpin for neuralink.
The sewing machine like robot that is the linchpin for neuralink.

Brain machine interfacing, as someone who does research in the field and is getting a PhD in a brain machine interface lab, I think I’m qualified to comment on the progress neuralink. There’s a lot of hype out there, curing disease, ending paralysis, a world where we are part of the machine and the machine is part of us. Is it science fiction, or is there more to it?

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Fact or artifact

Does it belong in a museum though?

A new turn in the saga of my data processing. There has been some concern that the artifact from the stimulation is causing the thing I am seeing in my data. There are arguments to be made for both sides, but let’s go over what that could mean for me.

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So much data

This has basically been my progression in this project.

Well I’ve processed (poorly) about half of my data. Now, when I say poorly I just mean the visuals for it are garbage and I need to tweek the sizes and things to make it look nicer, but the idea is that I’m more interested in finding something than I am in making it look pretty. I’ve processed two of four of my subjects and well I’m excited!

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The after

I’m trying to remain calm. I am an objective observer in the world of science and whatever the result, I will NOT let it cloud my emotions. I am neutral and I will remain that way… oh who am I kidding, I DID IT! Two years of planning and convincing people this would work. Then last night I had my first result, and it was a relief. It was a small step, but one I was afraid the data wouldn’t let me make.

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Into the unknown

Time to cross that bridge…

Today is going to be a somewhat anxious day for me. It’s the day I get to crack open my data and see what spills out. There was a process to get to this point of course, it took me about a week, but today with just a few clicks I’m going to see if I have something or if my idea was never meant to be.

Read more… if you dare!

A busy day!

Yep I use this image a lot, but it’s such a great representation of our labs work!

Well I didn’t plan for it, but today is a busy day! I’ve got a lot going on at the moment so not a lot of time to write. Let’s just talk about what I’ve done and have left to do so I can get back to it.

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Process the data!

This is what raw EEG data looks like. Seriously, it’s a bunch of squiggles. However, we can make sense of it and we can even write some code to make sense of it in real-time so you can control things with your brain!!! <EVIL LAUGH>

It’s a process… that’s for sure. So you’re a scientist and you collect a ton of data, well now what? We’re talking about me of course. I did it, I collected a ton of data and now I need to do something useful with it. This is the part I wish I could skip over and get to the part where I get all the cool results, but I guess we’ve all got to start somewhere.

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Day 362: Experiment two

Just a giant case full of the equipment I borrowed from my university for experiments. Pretty sure the school’s office staff thing I was robbing the place though.

Well today is going to be a quick recap of my experiment yesterday. This will be just as much for me as it is for all of you. While I can’t go into the experiment details (since I’m working to publish this) I can give a pretty good overview like I did the last time around.

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Day 361: Accidental history

Impostor syndrome
Art by: xkcd

Ever wake up one morning and realize you’re exactly where you wanted to be. That you’re in a place you never even dared to dream you could reach because, well it was silly to think you could accomplish something like that. Dreams that big weren’t meant for people like you, so you didn’t even bother to think you could get there. Yet… here we are.

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Day 360: Second experiment

Computer

The computer I use to process all my data, even with this it takes FOREVER to finish processing.

Well tomorrow is my second experiment. To be clear, it’s technically the same experiment, just a second person, so maybe it would be better to call it trial two? In any case, while the last one went (mostly) well, there are a few things I’m changing to make this next one even better. Sometimes when you prep for an experiment, you don’t realize what you’re forgetting until you can’t do it, so we’re correcting that this time.

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Day 358: One small step

Dream big

Sometimes are points in life that you can clearly define as the before and the after. As a child sometimes those points are simple milestones growing up, starting a new school for example or moving to a new town. There is the before and the after. As you get older those points become few and far between. For example, you started a new job. Unless it’s your dream job, you don’t really think of it as one of these points and everything just blurs together. Thus the bar seems to get higher and higher as we age. Today I had one of those points.

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Day 357: Thoughts from the lab

Case

My giant very suspicious case full of equipment from my school lab.

Well today is a busy day! I’ve got a lot going on so hopefully by the time you read this I’ll have all the setup taken care of. Working in two labs seems like a fun and interesting way to do experiments and it is! It’s also a huge pain.

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Day 326: Review: The state of spinal cord research

Figure 2 from and yet it moves

Figure 2 from and yet it moves

Facilitation of stepping-like volitional oscillations using non-invasive transcutaneous electrical spinal cord stimulation in SCI subject. (A) Position of the participant in the gravity-neutral apparatus. (B) Biphasic electrical stimulation was delivered using unique waveforms consisting of 0.3–1.0 ms bursts filled by 10 kHz frequency that were administered at 5–40 Hz. (C) EMG activity of right soleus (RSol), right tibialis anterior (RTA), right medial gastrocnemius (RMG), right hamstrings (RHam), right vastus lateralis (RVL), right rectus femoris (RRF) and angular displacement in the knee and hip joints of both legs during leg oscillations with a voluntary effort alone (Vol), stimulation at T11 (Stim), and Vol + Stim are shown. (D) Schematics demonstrating the approximate location of transcutaneous electrodes above the lumbosacral enlargement, in relation to the location of the motor pools based on Kendall et al. (1993) and Sharrard (1964).

Well it’s been two weeks (roughly) and my PI asked specifically that this week I do a review on the state of spinal cord research, with emphasis on the spinal cord stimulation work I’m doing. So this review is going to look slightly different, namely it has a rather long references section (15 total). If you find this research fascinating I recommend “And yet it moves” (reference 5). It’s long, but open access and worth the read. I’m a little bias though, my Co-PI is one of the authors. In any case, I had two weeks to write this, so hopefully it is a good dip into what we know about the spinal cord and a lot of what we don’t. Enjoy!

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Day 318: The why.

parts

With everything going on it’s been tough to write about just one topic. When I started 365 days, I started it with the intention of highlighting my struggles and trials through one full year of my PhD with the idea that I may (or may not) keep going for the duration of my PhD process. Then COVID hit, Black lives matter protests took off (finally), and I had the realization that I, like most people, am more than just my studies.

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Day 317: Mental health and you

neural symphony

I scream it loudly from the mountain tops, I suffer all the fucking time from mental health issues. I do it because staying silent doesn’t keep me from feeling them and it does nothing for others who are suffering. Yes, it’s embarrassing to talk about it because it feels like a taboo, or something you’re making up, but that’s why we need to talk about it and why you need to keep track of your own mental health.

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