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Posts tagged “medicine

The legacy we leave behind

Well it’s still that time of the year for me, the time where my anxiety is pegged at an 11, the stupid feelings inside my head keep telling me others would be better off without me, and honestly I start to believe it because who do I have besides myself? It’s exhausting, painful (in the literal sense), and I hate it. This time of the year also seems to come with a fair bit of bad luck. In this case, another death.

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A senseless death

I’m angry. Mostly I’m hurt, but I’m very angry. Angry about misinformation, angry about lies, and people wanting to profit from killing others. I’m angry that there is a small, but incredibly vocal group of anti-vaccine, anti-mask, pro-death cultists basically that are causing people to question if the COVID vaccine is safe. And today I found out we lost someone close to us because of that misinformation.

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The death of hope

Maybe I’m being over dramatic, who knows. It’s been a struggle and yes, today is not a good day. Not that many days around this time of the year are good, but today in particular is a bad one. Depression sucks and the thing about depression is that it’s hard to explain to others, especially if you’ve never had to deal with clinical depression or if you’re like me, had to live with chronic treatment resistant depression.

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A rough landing

My joints hurt, like all of them. It feels like stabby burny pain. It’s not fun, but I’ve seen this kind of thing happen just once before in my life (here). Spoiler, it’s somehow related to stress, the last time this happened I was very stressed out and this time it’s back, but worse. It’s not a fun time for me obviously, so today is a mixed bag, both good news and bad.

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So you’re nervous about the COVID vaccine

Welcome. First I guess we should make it clear, I’m vaccinated, I’ve been vaccinated, and I got vaccinated early on. If you’re reading this and not a regular around here, then you’re probably looking for some good information about the vaccine to help assuage your fears. The good news is that if you’re here you probably want someone to tell you that it’s okay, that the vaccine is safe, and that you should get it. Well I’m happy to do that for you.

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The week ahead

There’s a lot happening this week, it SHOULD be the last week I’m technically jobless. Right now I’m not getting paid by anyone, not by the school, not by the hospital, basically I’m living off the last paycheck I got at the beginning of the month and the next one may not be here until close to the end of next month. If something happens and my start date gets pushed back, well that would mean that I would have no money for anything. That would be bad.

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The transition to clinical research

Today should be interesting… it’s my onboarding appointment, which is one of the last steps I need to complete to be hired at the hospital. There’s a lot going on in life at the moment, some of which is personal so I won’t be sharing that here, but let’s just say everything has been incredibly stressful. Oh and since I need to get the appointment done this week if I want to start on time, this was the last day I can get it done.

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The uncertain future

old door in middle of field, which opens to a whole different world.
old door in middle of field, which opens to a whole different world.

My Co-PI is leaving! Or maybe he’s not? But he could be?! I don’t even know. It doesn’t help that he has no idea and there’s no real deadline for him to make a choice, it’s whenever he’s ready. In fact, we currently have a line graph with his daily percentage on staying or leaving. I wish I was joking. It’s not just my future I’m worried about, there are others in the lab, most of us wouldn’t be able to make the journey to his new workspace, even if we wanted to (and trust me when I say if I could, I would).

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A small success

It was a leap of faith. There were no good choices, but it was the best of options in a string of bad options. I could either work full time in my main-PI’s lab, pulling me away from the clinical research I love, or I could take a job in my Co-PI’s lab. The catch was to take the job with my Co-PI I would have to apply, wait, and go through the onboarding process. That would mean I wouldn’t be getting paid, which would be okay for a few weeks, but longer and I could be in trouble. Nothing is finished yet, but I’ve gotten some good news.

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Sometimes it rains

Brains are wild. I mean we have this misshapen jello blob stuck in our head and it somehow gives us the ability to be aware. We exist and think, feel, reason, all the stuff that makes us who we are. Brains are great, except when they aren’t. Depression is a horrible thing, which lives in the brain. You can’t “just be happy” anymore than someone could just be rich. Obviously when you live with chronic depression you got a dud of a brain. It may have to do with genetics, environmental factors, the way we were raised, or maybe it’s just horrible luck, but out of all the organs we can fix or replace, the brain is not one of them. You’re stuck as you and sometimes that sucks.

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COVID Vaccine: The third shot update!

It’s been over 36 hours since my third dose of COVID vaccine. For those who don’t know, I was designated as a vulnerable population and the veterans administration (VA) is apparently giving out the third dose to us now and to the general veteran population in the next month or two. Since I was one of the first getting my last two doses, I thought it would be wise to chronicle my experience.

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COVID Vaccine: The third shot!

It’s official, I got my third COVID vaccine shot. With delta ramping up and the long-term effectiveness of the vaccine being questioned there has been a push for a third shot. mRNA vaccines had the promise of being easily adaptable to new strains, it’s why we’ve been doing research on them since the mid-60’s, so it would’ve been prudent to adjust the vaccine to compensate for the new pervasive strain. Alas! It was not meant to be, at least not yet. It’s a little frustrating, but I am hopeful new variants of the vaccine will be forthcoming. So why did I get the shot?

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A funeral is for the living

The steady climb of the death toll from the pandemic is once again ramping back up as more people are exhausted from living like… well like we are living in a pandemic. Misinformation and outright lies are being passed around as truth. What’s worse is the people arguing that COVID is not an issue treat the incredibly high and incredibly senseless amount of death that is a direct result of callous disregard for others as an acceptable price for the right to be selfish. I saw enough senseless death in the military to want to be the direct cause of more. But maybe that’s just me.

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You still need to wear the damn mask

I know, it’s been a long pandemic. I’m tired, your tired, so, so many people are dead. It’s a lot, hell it’s a plot of dozens of horror movies, but it’s not over. So once again I am begging my lovely readers to wear the damned mask. I know there is a lot of confusing information out there. Some of it says don’t bother with the mask, some tells you wear one if you’re not vaccinated, it feels mixed signals sure sure. Well let me make it incredibly simple, wear the damn mask. You put on pants when you go outside, wear the damn mask.

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Technical problems

While people worried about the robot apocalypse, I’m not. If I need to randomly turn my router off and back on again for it to work properly I doubt Skynet will somehow gain sentience and take over the world without someone needing to go in and reboot it from time to time. Technology is an imperfect thing, like biology, but we expect technology to be better than us at what we need it to do. Today we spent almost an hour doing a little dance with the technology in the lab trying to get all the pieces to play nicely. The robot apocalypse will be short lived.

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My talk is today and you’re all invited!

Okay so I wanted to update everyone on how my first lecture went yesterday since I only had a few short days to throw everything together and it was a mad panic to the end. Unfortunately we cannot go into detail today! That’s because today is my “I’m giving a talk” talk (which I wrote about here). It’s free to watch, my talk is roughly four minutes long and is a nice little rundown of some of the work I do. So today I figure I will go into a bit of detail and should you be so inclined to attend you’ll get the chance to chat with me in person about my work! Yep, I’m breaking anonymity yet again, but it’s for a good reason.

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And nothing was wrong with me…

Last summer I had some sort of autoimmune thing kick up. Frankly I’m not sure it was autoimmune or what the hell it was, but it hurt, left me feeling exhausted, and caused my hands, face, and elbows to form raised red spots that later peeled off (here). It was incredibly painful, made me question the minor breakouts of whatever it was that had been going on for a good ten years or so prior, and was a red flag that I was not okay. But the pandemic has been ongoing so getting attention from the VA, which is notoriously awful, had been difficult. Had been, I finally got the chance to see someone.

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Surgical shadow update!

Well I finished my surgical shadow today. Frankly I’m exhausted, maybe I was just too excited, but I got roughly zero sleep last night. That said, it went better than the last shadow where I had just gotten my second dose of vaccine the day before. Now that was not my idea of a fun time! So per the usual I cannot go into the details, but I can talk vaguely about what happened and what’s next.

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Another surgical shadow

Just FYI, I didn’t take this and I’m pretty sure it’s just a stock photo, but it works for the post. I wouldn’t want to cause any privacy issues.

Well it’s officially on the books! Monday (super early) morning I will be shadowing my second surgery. For those new around here this was the first. It was an awesome experience and I’m excited to do it again. Today we’ll talk about why I, as someone who does non-invasive research, is even attending surgeries and what I get out of them. There is an actual practical reason to attend, but it’s also just super interesting!

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VA healthcare in a pandemic

With the pandemic stretching now over a year, which really feels like twenty, eventually healthcare was going to be an issue for me. I’ve already had to have a surgery during the pandemic, which was nerve wracking not because of the surgery, but because of COVID. Well it’s become a struggle to keep trying to put off getting care when I’m someone who needs pretty regular care. I went from bi-weekly appointments to once every 6 months or more, not ideal.

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I got my COVID Vaccine – update

Well today is day 1 post COVID vaccine. That was the first of two shots that I need to get, the second one will be in the middle of January (already scheduled). Since I was lucky enough to get the vaccine I thought I would talk a bit about the side effects of it, at least from my end. My hope is to help people relax a bit and when it becomes available to the public, you won’t be nervous to get it done.

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On the importance of vaccines

Once upon a time polio was more feared than the atomic bomb. Thanks to the vaccine we’ve practically (not completely mind you!) eliminated polio from the planet. We successfully eliminated smallpox, the only existing strains live in special labs now. Vaccines are a triumph of science and are so successful that people have forgotten they are necessary for a reason. In short, vaccine fear is a byproduct of vaccine success.

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Funding and you, a PhD story

New day, yet another topic for me to talk about. Today I’ve decided to spare everyone from hearing about my data processing woes to instead touch on a topic that I haven’t discussed before (at least I don’t think I have!). Today we’re talking about funding your PhD. Specifically why it’s important and what power you have over the funding you recieve.

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Surgery time

Well today is the day. I just checked in and ready for surgery. For those of you who follow along, this isn’t the first surgery I’ve had. I’ve had two surgeries a year for the past four years. It’s a lot, but each one offers the promise of a slightly better life.

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Day 325: Religious freedom and you

Bill-of-Rights

I’m not here to tell you how to live your life. Then again, that’s the point of the post. The United States was founded on the idea that we can believe, or not believe, whatever we want and the government would not do anything to impose one religion on people above any other. We’ve failed miserably, but that was decades in the making.

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Day 133: The truth of VA healthcare

VA Hospital

I’m a disabled Marine veteran. From a TBI to my mental health, I’ve got some serious issues. Furthermore, with the rate of suicide among veterans ever increasing it may be odd to an outsider why this is happening. After all, the government provides us with free healthcare, why are so many of us dying, why are so many of us killing ourselves? The answer is sadly straightforward, although grim, so let’s talk healthcare as a veterans.

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Red meat and organs may pose a significant health hazard

cooked steak

cooked steak

Neu5Gc, a non-human sialic acid sugar molecule common in red meat that increases the risk of tumor formation in humans, is also prevalent in pig organs, with concentrations increasing as the organs are cooked, a study has found. The research suggests that Neu5Gc may pose a significant health hazard among those who regularly consume organ meats from pigs.

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A new view of the immune system

t cells

t cells

Pathogen epitopes are fragments of bacterial or viral proteins. Attached to the surface structure of cells, they prompt the body’s immune system to mount a response against foreign substances. Researchers have determined that nearly a third of all existing human epitopes consist of two different fragments. Known as ‘spliced epitopes’, these types of epitopes have long been regarded as rare. The fact that they are so highly prevalent might, among other things, explain why the immune system is so highly flexible.

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Oligodendrocyte selectively myelinates a particular set of axons in the white matter

axon

axon

There are three kinds of glial cells in the brain, oligodendrocyte, astrocyte and microglia. Oligodendrocytes myelinate neuronal axons to increase conduction velocity of neuronal impulses. A Japanese research team found a characteristic feature of oligodendrocytes that selectively myelinate a particular set of neuronal axons.

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Cold medicine could stop cancer spread

cold medicine

cold medicine

Bladder cancer is the seventh most common cancer in males worldwide. Every year, about 20,000 people in Japan are diagnosed with bladder cancer, of whom around 8,000–mostly men–succumb to the disease. Bladder cancers can be grouped into two types: non-muscle-invasive cancers, which have a five-year survival rate of 90 percent, and muscle-invasive cancers, which have poor prognoses.

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Female brains change in sync with hormones

brain

brain

Although it has already been known for some time that the brain does not remain rigid in its structure even in adulthood, scientists have recently made a surprising discovery. The brain is not only able to adapt to changing conditions in long-term processes, but it can do this every month.

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Untangling a cause of memory loss in neurodegenerative diseases

memory loss

memory loss

Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease that are characterized by the deposition of aggregates of the tau protein inside brain cells. A new study reveals that the cutting of tau by an enzyme called caspase-2 may play a critical role in the disordered brain circuit function that occurs in these diseases.

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High cholesterol triggers mitochondrial oxidative stress leading to osteoarthritis

knee problems

knee problems

High cholesterol might harm more than our cardiovascular systems. New research using animal models suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die, and ultimately leading to the development of osteoarthritis.

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Vitamins A and C help erase cell memory

epigenetics

epigenetics

Vitamins A and C aren’t just good for your health, they affect your DNA too. Researchers have discovered how vitamins A and C act to modify the epigenetic ‘memory’ held by cells; insight which is significant for regenerative medicine and our ability to reprogramme cells from one identity to another.

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Doc versus machine

webMD cancer scare

webMD cancer scare

Increasingly powerful computers using ever-more sophisticated programs are challenging human supremacy in areas as diverse as playing chess and making emotionally compelling music. But can digital diagnosticians match, or even outperform, human physicians? The answer, according to a new study, is “not quite.”

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Revising the meaning of ‘prion’

mad cow disease

mad cow

A team of scientists are redefining what it means to be a prion–a type of protein that can pass heritable traits from cell to cell by its structure instead of by DNA. Although prions are infamous for causing Creutzfeldt-Jakob disease, fatal familial insomnia, and bovine spongiform encephalopathy, commonly known as mad cow’s disease, the present study indicates that prions identified in yeast, and possibly in plants, and other organisms may be beneficial.

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For women, caffeine could be ally in warding off dementia

dementia coffee drinking

dementia coffee drinking

Among a group of older women, self-reported caffeine consumption of more than 261 mg per day was associated with a 36 percent reduction in the risk of incident dementia over 10 years of follow-up. This level is equivalent to two to three 8-oz cups of coffee per day, five to six 8-oz cups of black tea, or seven to eight 12-ounce cans of cola.

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Omega-3 fatty acid stops known trigger of lupus

fish oil

fish oil

A team of researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders. DHA can be found in fatty, cold-water fish and is produced by the algae that fish eat and store in their bodies. It can be found in fish oil supplements as well, used by more than 30 million Americans.

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Children could point the way to new HIV treatments

HIV Aids

HIV Aids

Children with HIV who can resist the disease progressing could point the way to new treatments for HIV infection that are more widely applicable to infected adults and children alike, an international team of researchers has found.

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Why do more men than women commit suicide?

Depression

Depression

Why do more men die when they attempt suicide than women? The answer could lie in four traits, finds scientists. There are over 6,000 British lives lost to suicide each year, and nearly 75 per cent of those are male. However, research has found women are more likely to suffer from depression, and to attempt to take their own life.

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Linking perception to action

perception

perception

Researchers studying how the brain uses perception of the environment to guide action offer a new understanding of the neural circuits responsible for transforming sensation into movement.

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Historical analysis examines sugar industry role in heart disease research

high sugar content

high sugar content

Using archival documents, a new report examines the sugar industry’s role in coronary heart disease research and suggests the industry sponsored research to influence the scientific debate to cast doubt on the hazards of sugar and to promote dietary fat as the culprit in heart disease.

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The new findings heart repair research

broken heart

broken heart

Scientists trying to find ways to regenerate a damaged heart have shed more light on the molecular mechanisms that could one day make this a reality.  Whilst other organs such as the liver can regenerate, the heart muscle has very little ability to do so after suffering damage, such as a heart attack.
In the womb the body is able to produce heart muscle cells but soon after birth it effectively stops producing them.

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Study could herald new treatment for muscular dystrophy

muscular dystrophy fun

muscular dystrophy fun

New research has shown that the corticosteroid deflazacort is a safe and effective treatment for Duchenne muscular dystrophy. The findings could pave the way for first U.S.-approved treatment for the disease.

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Antimicrobial chemicals found with antibiotic-resistance genes in indoor dust

pokemon evolution

pokemon evolution

Researchers have found links between the levels of antimicrobial chemicals and antibiotic-resistance genes in the dust of an aging building used for athletics and academics. One of the antimicrobials seen in the study is triclosan, a commonly used antibacterial ingredient in many personal care products.

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Drugs in the water? Don’t blame the students

drugs on tap

drugs on tap

With nearly sixty percent of American adults now taking prescription medications–from antidepressants to cholesterol treatments–there is growing concern about how many drugs are flowing through wastewater treatment facilities and into rivers and lakes. Research confirms that pharmaceutical pollution can cause damage to fish and other ecological problems–and may pose risks to human health too.

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Babies chew on subtle social, cultural cues at mealtime

baby eating food

baby eating food

At the dinner table, babies do a lot more than play with their sippy cups, new research suggests. Babies pay close attention to what food is being eaten around them – and especially who is eating it. The study adds evidence to a growing body of research suggesting even very young children think in sophisticated ways about subtle social cues.

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Trauma’s epigenetic fingerprint observed in children of Holocaust survivors

I swear I didn't kill anyone

I swear I didn't kill anyone

Image credit goes to the one and only — very talented — Lora Zombie

The children of traumatized people have long been known to be at increased risk for posttraumatic stress disorder (PTSD), and mood and anxiety disorders. However, there are very few opportunities to examine biologic alterations in the context of a watershed trauma in exposed people and their adult children born after the event.

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Caffeine reverts memory deficits by normalizing stress responses in the brain

coffee brain

coffee brain

A new study describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals. The international teams showed that the abnormal expression of a particular receptor – the adenosine A2A, target for caffeine – in the brain of rats induces an aging-like profile namely memory impairments linked to the loss of stress controlling mechanisms.

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Use it or lose it: Stopping exercise decreases brain blood flow

Brain exercise

Brain exercise

We all know that we can quickly lose cardiovascular endurance if we stop exercising for a few weeks, but what impact does the cessation of exercise have on our brains? New research examined cerebral blood flow in healthy, physically fit older adults (ages 50-80 years) before and after a 10-day period during which they stopped all exercise.

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