Pain, it’s a pain, it always seems to find ways to pop up when you least expect it, enter non-aspirin! Better known as acetaminophen, it has been known for centuries that is an effective painkiller. Since it is over the counter most people don’t give it a second thought, but according to a new study, it could also be impeding error-detection in the brain.
Chronic pain results from disease or trauma to the nervous system. Damaged nerve fibres with heightened responses to normal stimuli send incorrect messages to pain centres in the brain. This phenomenon, called “peripheral and central sensitization” is one of the key mechanisms involved in the condition which touches people with diabetes, cancer, and those suffering from multiple sclerosis, among others.
Placebos have helped to ease symptoms of illness for centuries and have been a fundamental component of clinical research to test new drug therapies for more than 70 years. But why some people respond to placebos and others do not remains under debate.
With the advent of genomics, researchers are learning that placebo responses are modified by a person’s genetics, a discovery that raises important new questions regarding the role of the placebo in patient care and in drug development: How many genetic biomarkers exist? Can the medical field harness the placebo response to enhance personalized medical treatment? What might be the impact of placebo-drug interactions? And what will this new information mean for randomized clinical trials, which depend on placebo controls to test the efficacy of new drug candidates? Should a “no-treatment” control be added to future trials?
In today’s society, when it is so easy to over medicate children and adults alike it is nice to finally read something that looks for an alternative option. This particular case deals with pain management in children post surgery and the study shows that pediatric patients who listened to 30 minutes of songs by Rihanna, Taylor Swift and other singers of their choosing — or audio books — had a significant reduction in pain after major surgery.
Pain typically has a clear cause–but not always. When a person touches something hot or bumps into a sharp object, it’s no surprise that it hurts. But for people with certain chronic pain disorders, including fibromyalgia and phantom limb pain, even a gentle caress can result in agony and for some — like my sister — the pain can be almost never ending.
My sister suffers from chronic pain issues. I’ve written several posts about how her autoimmune disease is a special brand of pain that you will thankfully (almost certainly) never have to feel. While great strides have been made in pain management, there are still relatively few options that do not carry the risk of being extremely addictive. Well thankfully there is some new research and it offers hope, not just for my sister, but for the millions of people suffering from chronic pain that has been poorly managed.
Pain is… well a pain. As it turns out pain does more than just hurt. A study just released shows that chronic pain not only lowers life expectancy, but can also slow the metabolism.