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Archive for October 12, 2015

Supercoiled DNA is far more dynamic than the ‘Watson-Crick’ double helix

Supercoiled DNA is far more dynamic than the 'Watson-Crick' double helix

The image shows the structure of the DNA calculated with the supercomputer simulations (in colour) superimposed upon the cryo-electron tomography data (in white or yellow). (There is no superimposition onto cryo-electron tomography data for the purple figure-8 shape.) You can see that the familiar double helix has been either simply bent into a circle or twisted into a figure-8. Image credit goes to: Thana Sutthlbutpong

Researchers have imaged in unprecedented detail the three-dimensional structure of supercoiled DNA, revealing that its shape is much more dynamic than the well-known double helix.

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