Researchers at the University of Minnesota have engineered a new synthetic biopathway that can more efficiently and cost-effectively turn agricultural waste, like corn stover and orange peels, into a variety of useful products ranging from spandex to chicken feed.
A central challenge in the field of metabolic engineering is the efficient identification of a metabolic pathway genotype that maximizes specific productivity over a robust range of process conditions. A review from researchers at Michigan State University in East Lansing, MI covers the challenges of optimizing specific productivity of metabolic pathways in cells and new advances in pathway creation and screening.
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell. The engineered ribosome may enable the production of new drugs and next-generation biomaterials and lead to a better understanding of how ribosomes function.
Living cells can make a vast range of products for us, but they don’t always do it in the most straightforward or efficient way. Shota Atsumi, a chemistry professor at UC Davis, aims to address that through “synthetic biology:” designing and building new biochemical pathways within living cells, based on existing pathways from other living things.
The DNA encoding all life on Earth is made of four building blocks called nucleotides, commonly known as “letters,” that line up in pairs and twist into a double helix. Now, two groups of scientists are reporting for the first time that two new nucleotides can do the same thing — raising the possibility that entirely new proteins could be created for medical uses.
Like mad scientists working away in some secret location we have created life… well sort of. It may sound like something out of a Sci fi movie, but scientists have created the world’s first enzymes made from artificial genetic material. Their synthetic enzymes (which are made from molecules that do not occur anywhere in nature) are capable of triggering chemical reactions in the lab and are the building blocks for life.
Ever think you could have built something better if you had a hand in the design? Sometimes people just have a desire to make, after all the maker movement is huge for a reason. Well geneticists have a new
toy tool to play with —dubbed “the telomerator”—that could redefine the limits of synthetic biology and advance how successfully living things can be engineered or constructed in the laboratory based on an organism’s genetic, chemical base-pair structure. How cool is that?!