Advertisements

We're a little crazy, about science!

Where memory is encoded and retrieved

Where memory is encoded and retrieved

Are the same regions and even the same cells of the brain area called hippocampus involved in encoding and retrieving memories or are different areas of this structure engaged? This question has kept neuroscientists busy for a long time. Researchers at the Mercator Research Group “Structure of Memory” at RUB have now found out that the same brain cells exhibit activity in both processes.

In the course of their project, Dr Nozomu Nakamura and Prof Dr Magdalena Sauvage from the work group “Functional Architecture of Memory” (FAM) focused on the brain region hippocampus. This seahorse-like structure plays a crucial role in the formation of long-term memories and later in retrieving of memory contents. This has been demonstrated in patients with amnesia or in elderly people in which cases damage to this structure correlates to severe memory deficits.

For their studies with rats, researchers adapted a standardised word-based memory test for humans, using however scents instead of words. The researchers hid small treats in sand-filled cups. In addition, each cup also contained a different scent, such as thyme or coriander which could be smelled by the rats when searching for the treats.

Each training unit consisted of three phases. During the learning phase, researchers presented several scents to the animals. A pause followed, and subsequently a recognition phase. In the latter, the animals were presented the scents from the learning phase as well as other smells. The animals demonstrated that they recognised a scent from the learning phase by running to the back wall of their cage, where they were rewarded with food for the correct response. If, on the other hand, they recognised that a scent had not been presented during the learning phase, they demonstrated it by digging in the sand with their front paws.

Using molecular imaging, researchers subsequently identified the regions and the cells of the hippocampus in which activity during encoding and retrieval was predictive of accurate memory performance. To this end, they detected mRNAs from different activity markers closely tied to memory function. The results showed that those cells were exclusively located in the rats’ upper region of the hippocampus, which in humans corresponds to the posterior part of the hippocampus.

Moreover, they could show that the same cells were engaged during the encoding and the retrieval of the memory.

“The debate whether the same or different hippocampus regions are involved in both processes is a long-standing one,” says Prof Dr Magdalena Sauvage.

“The unique aspect of our approach is that we were able to analyse each single cell and, consequently, brought compelling evidence that the same cells are engaged during the formation and the retrieval of memories.”

Sources:
Nakamura, N., & Sauvage, M. (2015). Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus Hippocampus DOI: 10.1002/hipo.22491

Advertisements

One response

  1. They could analyse each single cell? Wow.

    July 28, 2015 at 11:51 am

But enough about us, what about you?

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s