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Autism and Pesticides: What, too obvious?

Autism children

There have been a few different things linked to children who fall under the Autism Spectrum Disorder. A combination of genetic and environmental factors, along with complications during pregnancy have been associated with the diagnoses. And a new study aims to strengthen the link between prenatal exposure to pesticides and autism [Please hold your collective duh’s until the end]. The large, multi-site California-based study examined associations between specific classes of pesticides, including organophosphates, pyrethroids and carbamates, applied during the study participants’ pregnancies and later diagnoses of autism and developmental delay in their offspring.

The study found that pregnant women, who lived in close proximity to fields and farms where chemical pesticides were applied experienced a two-thirds increased risk of having a child with autism spectrum disorder or other developmental delay. Autism Spectrum Disorder effects nearly 1 in 68 children here in the US alone, and a two-thirds increase at any rate is sad to say the least.

“This study validates the results of earlier research that has reported associations between having a child with autism and prenatal exposure to agricultural chemicals in California,” said lead study author Janie F. Shelton, a UC Davis graduate student who consults with the United Nations. “While we still must investigate whether certain sub-groups are more vulnerable to exposures to these compounds than others, the message is very clear: Women who are pregnant should take special care to avoid contact with agricultural chemicals whenever possible.”

A little background, California is the top agricultural producing state in the nation, grossing $38 billion in revenue from farm crops in 2010. So of course, the statistic which shows the statewide use of approximately 200 million pounds of active pesticides which are applied to the crops each year shouldn’t be surprising. Most of that is used in the Central Valley, north to the Sacramento Valley and south to the Imperial Valley on the California-Mexico border. While I would argue pesticides are critical for the modern agriculture industry, certain commonly used pesticides are neurotoxic and may pose threats to brain development during gestation, potentially resulting in developmental delay or autism.

The study was conducted by examining commercial pesticide application. The researchers used the California Pesticide Use Report and then they linked the data to the residential addresses of approximately 1,000 participants in the Northern California-based Childhood Risk of Autism from Genetics and the Environment (CHARGE) Study. The study included families with children between ages 2 and 5 diagnosed with autism, developmental delay, or with typical development. The majority of study participants live in the Sacramento Valley, Central Valley and the greater San Francisco Bay Area.

Twenty-one chemical compounds were identified in the organophosphate class, including chlorpyrifos, acephate and diazinon. The second most commonly applied class of pesticides was pyrethroids, one quarter of which was esfenvalerate, followed by lambda-cyhalothrin permethrin, cypermethrin, and tau-fluvalinate. Eighty percent of the carbamates were methomyl and carbaryl [I know, lots of links and big words, my eyes glaze over sometimes too. I recommend you just remember they are different types of pesticides, but for those who want more information, you have it].

For the study, researchers used questionnaires to obtain study participants’ residential addresses during the pre-conception and pregnancy periods. The addresses then were overlaid on maps with the locations of agricultural chemical application sites based on the pesticide-use reports to determine residential proximity. The study also examined [of course] which participants were exposed to which agricultural chemicals.

“We mapped where our study participants’ lived during pregnancy and around the time of birth. In California, pesticide applicators must report what they’re applying, where they’re applying it, dates when the applications were made and how much was applied,” Hertz-Picciotto said. “What we saw were several classes of pesticides more commonly applied near residences of mothers whose children developed autism or had delayed cognitive or other skills.”

What the researchers found was that during the study period, approximately one-third of CHARGE Study participants lived in close proximity — defined as within 1.25 to 1.75 kilometers — of commercial pesticide application sites. Some associations were greater among mothers living closer to application sites and lower as residential proximity to the application sites decreased..

Organophosphates applied over the course of pregnancy were associated with an elevated risk of autism spectrum disorder, particularly for chlorpyrifos applications in the second trimester. Pyrethroids were moderately associated with autism spectrum disorder immediately prior to conception and in the third trimester. Lastly, carbamates applied during pregnancy were associated with developmental delay.

The researchers noted that exposures to insecticides for those living near agricultural areas may be problematic, especially during gestation, because the developing fetal brain may be more vulnerable than it is in adults. Because these pesticides are neurotoxic, in utero exposures during early development may distort the complex processes of structural development and neuronal signaling, producing alterations to the excitation and inhibition mechanisms that govern mood, learning, social interactions and behavior.

“In that early developmental gestational period, the brain is developing synapses, the spaces between neurons, where electrical impulses are turned into neurotransmitting chemicals that leap from one neuron to another to pass messages along. The formation of these junctions is really important and may well be where these pesticides are operating and affecting neurotransmission,” Hertz-Picciotto said.

The research from the CHARGE Study has emphasized the importance of maternal nutrition during pregnancy, particularly the use of prenatal vitamins to reduce the risk of having a child with autism. While it’s impossible to entirely eliminate risks due to environmental exposures, Hertz-Picciotto said that finding ways to reduce exposures to chemical pesticides, particularly for the very young, is important.

“We need to open up a dialogue about how this can be done, at both a societal and individual level,” she said. “If it were my family, I wouldn’t want to live close to where heavy pesticides are being applied.”

I know it seems like everything these days is trying to kill us. But then again maybe that’s because we are trying to kill so many other things. Maybe in determining the safety of a chemical that could be on food, special attention should be done to research the effect it will have on the development of children and not just adults. Because it seems to me that the FDA assumes that because it is safe for adults, then it should be the same for children, which we know is not the case.

Even with all the chemicals you still want more? Then you probably want the full study, which can be found —here!

Sources
Shelton, J., Geraghty, E., Tancredi, D., Delwiche, L., Schmidt, R., Ritz, B., Hansen, R., & Hertz-Picciotto, I. (2014). Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural Pesticides: The CHARGE Study Environmental Health Perspectives DOI: 10.1289/ehp.1307044

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2 responses

  1. Pingback: Autism and Pesticides: What, too obvious? | Dr....

  2. Pingback: Finally! A Definite Cause of Autism: Hint it isn’t Vaccines | Loony Labs

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