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Archive for September 29, 2014

New Protein Implicated in Alzheimer’s

alzhiemers

Alzheimer’s prevention has made some strides in recent years. We’ve even identified some new causes, and in some cases we can do both. In fact,┬áresearchers have now shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer’s disease). These plaques can cause neuroinflammation, and worsen memory deficits in a mouse model of this condition. Conversely, by using a gene therapy approach to elevate progranulin levels, scientists were able to prevent these abnormalities and block cell death.

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