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Spines of boys and girls differ at birth

Spines of boys and girls differ at birth

Looking at measurements of the vertebrae – the series of small bones that make up the spinal column – in newborn children, investigators at Children’s Hospital Los Angeles found that differences between the sexes are present at birth. Results of the study suggest that this difference is evolutionary, allowing the female spine to adapt to the fetal load during pregnancy.

Using magnetic resonance imagining (MRI), the researchers found that vertebral cross-sectional dimensions, a key structural determinant of the vertebra’s strength, were 10.6 percent smaller on average in newborn females than in males.

“Human beings are the only mammals in which this difference is seen, and it is one of the few key physiological differences between the sexes,” said Vicente Gilsanz, MD, PhD.

“The reason could be that the spine has to move forward during pregnancy, so that the female can walk and maintain her center of gravity. Unfortunately, it also imparts a disadvantage in that it increases stress within the vertebrae for all physical activities, resulting in a great susceptibility for fractures later in life.”

“Although we’ve known that girls had smaller vertebrae than boys, we did not know how early this difference first occurred,” added Gilsanz, who is also professor of radiology at Keck School of Medicine of the University of Southern California.

“Our study indicates that the distinction between sexes is already present at birth, and provides new evidence that this difference begins during prenatal development of the axial skeleton.”

While the mechanisms responsible for the smaller female vertebral body during the fetal stages of skeletal development remain unknown, it likely results from complex interactions involving sex steroids, growth hormone and insulin-like growth factor.

In the study, 70 healthy, full-term newborns (35 boys and 35 girls) were measured. Weight, body length, and head and waist circumference did not significantly differ between sexes. Compared to newborn boys, girls had significantly smaller vertebral cross-sectional dimensions – a difference independent of gestational age, birth weight and body length.

The study notes that, over their lifetimes, women also accumulate less bone mass than men, resulting in a two- to four-fold increase in spinal fracture. A deficiency in vertebral growth in girls is associated with greater spinal flexibility and lower peak bone mass in young women, eventually resulting in an increased likelihood of scoliosis as well as osteoporosis in later life.

“While girls are born with a predisposition to developing osteoporosis as older adults, we know that bone development can be optimized with exercise and nutrition,” said Gilsanz.

“This is an example of how traits that might predispose an individual to disease can be mitigated through personalized medicine and customized health care, beginning early in life.”

Ponrartana, S., Aggabao, P., Dharmavaram, N., Fisher, C., Friedlich, P., Devaskar, S., & Gilsanz, V. (2015). Sexual Dimorphism in Newborn Vertebrae and Its Potential Implications The Journal of Pediatrics, 167 (2), 416-421 DOI: 10.1016/j.jpeds.2015.04.078

2 responses

  1. Kayla Knowlton

    Boys and girls are built different. Girls are built to have babies and boys are not. Boys are born built stronger. Boys are always perceived as being stonger than women, and that girls can’t be as strong as boys. For the most part this is true, guys have an advantage they born stronger. Boys and girls have different tasks here on earth, so why would girl ld girls even need to born stronger. They are stereotyped as a stay at home mom, to have children, cook, and clean. Psychologically girls are raised s fi they truly are weaker. They are comforted when they fall and get hurt and boys are not. Not only are guys but stronger, society portrays them as women being weak and males being strong.


    July 26, 2015 at 2:02 pm

    • I hate the gender role thing, I really hope that goes away as we evolve as a society. Women and men may be built differently given the biological tasks they are designed to perform, but I agree that doesn’t mean that women are weaker, in fact there are plenty of bodybuilding women who can and will tell you otherwise. Hopefully things come around, but this research does have a lot of implications for women developing osteoporosis or scoliosis, so that is a good thing.


      July 27, 2015 at 12:42 pm

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