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Where aging memories get stored in the brain

aging memories

Think back to when you were a child. Now instead, try to think of something that happened just a few minutes ago; would you believe that you are using different portions of the brain? When we remember events which occurred recently, the hippocampus is activated. This area in the temporal lobe of the brain is a hub for learning and memory. But what happens, if we try to remember things that took place years or decades ago?

Neuroscientists at the Ruhr-University Bochum and the Osaka University have been able to give some answers to this question. They reveal that the neural networks involved in retrieving very old memories are quite distinct from those used to remember recent events.

Neuroscientists agree that the hippocampus, which contains the cornu ammonis regions 1 and 3 (CA1 and CA3), plays a major role in retrieving recent memories. However, a major controversy in memory research resides on whether the hippocampus is also engaged when experiences date back half a lifetime or whether this is the role of the parahippocampal region of the brain: the cortical areas directly adjacent to the hippocampus.

A team of neuroscientists has monitored brain activity in mice during the retrieval of memories that are one day to one year old – e.g. up to the mouse-equivalent of 40 human years. For their study, they applied a high-resolution molecular imaging technique, which detects the expression of a particular gene tied to plasticity processes and this way sheds light on cognitive processes.

“For the very first time we were able to show that the retrieval of old and recent memories are supported by distinct brain networks”, Prof. Dr. Magdalena Sauvage reports.

The CA3 region — believed to be the place of memory storage in the hippocampus — no longer plays a role when we remember very old memories. Rather, the involvement of the CA1 region persists and the cortical areas adjacent to the hippocampus become involved. The reason for the differential involvement of the hippocampal subregions could lie in the mechanisms supported by CA3.

“In CA3, memories can be retrieved on the basis of single features of an original memory, which are used as cues. Since the memory for single features degrades over time, we speculate that they might ultimately be of no more use as cues, hence retrieving memory would then essentially rely on CA1 and other processes taking place in the parahippocampal region of the brain,” explains Prof. Sauvage.

Lux, V., Atucha, E., Kitsukawa, T., & Sauvage, M. (2016). Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval eLife, 5 DOI: 10.7554/eLife.11862

2 responses

  1. Edward Hilt

    This is quite exciting research being performed! Since the hippocampus is responsible for memory formation, it follows logically that short-term memories such as those from just a few minutes ago should be stored in this location. As the memories age, they spread to other regions of the cortex (the CA1 and CA3). As form follows function, the memories reasonably remain close to the source, the hippocampus. For future studies, the hypotheses proposed here should be tested further. Now that memory activity has been tested in mice, is similar activity observed in the human brain or are different pathways used for memory storage? For further mice studies, how is memory affected when the specific areas of the hippocampus mentioned become damaged?


    April 29, 2016 at 8:21 am

    • Brilliant, I agree that further study is needed. Seeing what happens to aging memories when specific areas of the hippocampus are damaged would be a great starting point.


      April 29, 2016 at 12:19 pm

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