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Posts tagged “vaccines

A new view of the immune system

t cells

t cells

Pathogen epitopes are fragments of bacterial or viral proteins. Attached to the surface structure of cells, they prompt the body’s immune system to mount a response against foreign substances. Researchers have determined that nearly a third of all existing human epitopes consist of two different fragments. Known as ‘spliced epitopes’, these types of epitopes have long been regarded as rare. The fact that they are so highly prevalent might, among other things, explain why the immune system is so highly flexible.

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Google searches for ‘chickenpox’ reveal big impact of vaccinations

digital epidemiology

digital epidemiology

Countries that implement government-mandated vaccinations for chickenpox see a sharp drop in the number of Google searches for the common childhood disease afterward, demonstrating that immunization significantly reduces seasonal outbreaks. That’s one of the findings from a new study that analyzed thousands of Google searches for “chickenpox.”

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What blocks pro-vaccine beliefs?

What blocks pro-vaccine beliefs?

Despite rhetoric that pits “anti-vaxxers” versus “pro-vaxxers,” most new parents probably qualify as vaccine-neutral–that is, they passively accept rather than actively demand vaccination. Unless there is an active threat of polio or whooping cough, they have to remind themselves that injecting their crying infant with disease antigens is a good thing.

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Vaccine clears some precancerous cervical lesions in clinical trial

Vaccine clears some precancerous cervical lesions in clinical trial

Scientists have used a genetically engineered vaccine to successfully eradicate high-grade precancerous cervical lesions in nearly one-half of women who received the vaccine in a clinical trial. The goal, say the scientists, was to find nonsurgical ways to treat precancerous lesions caused by HPV.

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New approach for making vaccines for deadly diseases

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

Researchers have devised an entirely new approach to vaccines – creating immunity without vaccination. The team has demonstrated that animals injected with synthetic DNA engineered to encode a specific neutralizing antibody against the dengue virus were capable of producing the exact antibodies necessary to protect against disease, without the need for standard antigen-based vaccination. Importantly, this approach, termed DMAb, was rapid, protecting animals within a week of administration.

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Some vaccines support evolution of more-virulent viruses

Some Vaccines Support Evolution of More-Virulent Viruses

This image shows chickens in agricultural production. Image credit goes to: Andrew Read, Penn State University

Scientific experiments with the herpes virus such as the one that causes Marek’s disease in poultry have confirmed, for the first time, the highly controversial theory that some vaccines could allow more-virulent versions of a virus to survive, putting unvaccinated individuals at greater risk of severe illness. The research has important implications for food-chain security and food-chain economics, as well as for other diseases that affect humans and agricultural animals.

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Educating the immune system: A vaccine for allergies

Allergies and allergy sufferers

With the arrival of spring, millions of people have begun their annual ritual of sneezing and wheezing due to seasonal allergies. However, a Canadian research team  is bringing them hope with a potential vaccine that nudges the immune response away from developing allergies. The findings have major clinical implications since allergies and asthma are lifelong conditions that often start in childhood and for which there is presently no cure.

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Whooping cough: A small drop in vaccine protection can lead to a case upsurge

Whooping-cough

In 2012 the USA saw the highest number of pertussis (whooping cough) cases since 1955. New research finds that a likely explanation for this rise in disease is a drop in the degree of vaccine protection for each vaccinated individual. The team worked with 60 years of pertussis disease data to determine what best explained the recent increase in the disease.

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