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We're a little crazy, about science!

Archive for June, 2016

Erasing unpleasant memories with a genetic switch

erasing memories

erasing memories

Researchers have managed to erase unpleasant memories in mice using a ‘genetic switch’.  Dementia, accidents, or traumatic events can make us lose the memories formed before the injury or the onset of the disease. Researchers have now shown that some memories can also be erased when one particular gene is switched off.

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Unlocking the secrets of nerve regeneration

nerve regenreation

nerve regenreation

Nerves in the central nervous system of adult mammals do not usually regenerate when injured. The granule cell, a nerve cell located in the cerebellum, is different. When its fibres, called parallel fibres, are cut, rapid regeneration ensues and junctions with other neurons called “synapses” are rebuilt. The precise mechanism for this was unclear.

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New method to grow and transplant muscle stem cells holds promise for treatment of MD

muscle

Satellite cells are stem cells found in skeletal muscles. While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro.

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Alzheimer’s genetics point to new research direction

Genetics of alzheimer's

Genetics of alzheimer's

A analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease. Previous research has revolved around the idea that accumulation in the brain of a small, sticky protein fragment — amyloid beta — causes Alzheimer’s disease.

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Genetic repeats suggest role for DNA instability in schizophrenia

schizophrenia

My friend has a glass eye and unless you knew the story you might not think anything of it. His older brother did it. You read that correctly, in a schizophrenic induced confusion he tried to killed him. He never held what happened against his older brother, he was sick, how could he? The courts say, he cannot visit his brother while he’s in prison. This could’ve been avoided with early detection and now international researchers have used a new technique to identify significantly more DNA sequence repeats in patients with schizophrenia than in control individuals.

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A new bio-ink for 3-D printing with stem cells

3d bioprinting

3d bioprinting

The new stem cell-containing bio ink allows 3D printing of living tissue, known as bio-printing. The new bio-ink contains two different polymer components: a natural polymer extracted from seaweed, and a sacrificial synthetic polymer used in the medical industry, and both had a role to play.

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Chemical changes in the brain affect Alzheimer’s disease

Alzheimer’s Disease Robs

Alzheimer’s Disease Robs

A new study is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The findings show that long-term suppression of the neurotransmitter acetylcholine – a target for anticholinergic drugs – results in dementia-like changes in the brain.

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In doctors we trust — especially when they admit to bias

Dr. Zoidberg

Dr. Zoidberg

A doctor’s guidance may reassure us more than we realize -especially if she says she is likely to recommend treatment in her field of expertise, known as “specialty bias.” Doing research in a real-world healthcare setting, researchers have found that when surgeons revealed their bias toward their own specialty, their patients were more likely to perceive them as trustworthy. And patients are more apt to follow their recommendation to have surgical treatment.

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Fear factor: A new genetic candidate for treating PTSD

I swear I didn't kill anyone
I swear I didn't kill anyone

Image credit goes to the very talented: Lora Zombie

Researchers have identified a new genetic candidate for testing therapies that might affect fear learning in people with PTSD or other conditions. Individuals with trauma- and stress-related disorders can manifest symptoms of these conditions in a variety of ways. Genetic risk factors for these and other psychiatric disorders have been established but do not explain the diversity of symptoms seen in the clinic – why are some individuals affected more severely than others and why do some respond better than others to the same treatment?

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Mothers with diabetes more likely to have anti-fetal brain autoantibodies

diabetes pregnancy

diabetes pregnancy

Mothers of children with autism and were diagnosed with metabolic conditions during pregnancy, particularly gestational and type 2 diabetes, were more likely to have anti-fetal brain autoantibodies in their blood compared to healthy women of children with autism. The presence of these anti-fetal brain autoantibodies has been previously found to be specific to some mothers of children with autism and rare among mothers of children without autism.

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Postpartum depression least severe form of depression in mothers

Postpartum depression

Postpartum depression

Postpartum depression–a household term since actress Brooke Shields went public in 2005 about her struggle with it–is indeed serious. But depression that begins before or during pregnancy is often more severe because it lasts longer and usually goes undetected until the doctor screens for it after the birth of the baby.

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Even when help is just a click away, stigma is still a roadblock

depression

depression

Stigma is a major barrier preventing people with mental health issues from getting the help they need. Even in a private and anonymous setting online, someone with greater self-stigma is less likely to take that first step to get information about mental health concerns and counseling.

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Experimental antibiotic treats deadly MRSA infection

antibiotics

antibiotics

The antibiotic arms race is on, while we are rushing to find new antibiotics, bacteria are working on finding ways around them. With that in mind, a new experimental antibiotic developed by a team of scientists successfully treats the deadly MRSA infection and restores the efficacy of a commonly prescribed antibiotic that has become ineffective against MRSA.

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Researchers show copper is essential for burning fat

weight loss cat

weight loss cat

Is copper deficiency contributing to the obesity epidemic? Though small amounts of copper are essential to health – oysters, liver, beans and nuts are good sources – copper’s role in metabolism has been unclear: Some studies found that it boosted fat burning, others that it depressed it.

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New tool brings personalized medicine closer

personalized medicine

personalized medicine

Scientists have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.

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Researchers watch skin cells ‘walk’ to wounds

bandaids

bandaids

New research is giving a whole new meaning to feeling your skin crawl. Skin cells typically spend their entire existence in one place on your body. But researchers have seen how the cells will alter the proteins holding them in place and move to repair a wound.

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Air pollution affects young people’s psychiatric health

air pollution in india

air pollution in india

Smog has been a part of modern life since the industrial revolution, unfortunately all that pollution isn’t just hurting the environment — but come on, you saw this coming… right? New research from Sweden indicates that dispensed medication for psychiatric diagnosis can be related to air pollution concentrations. More and more studies show that the brain and human cognitive development are affected by pollution.

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Mobilizing mitochondria may be key to regenerating damaged neurons

Neurons

Neurons

Mitochondria, sure it’s the powerhouse of the cell, but maybe it can be much more that. At least that’s what it looks like thanks to researchers at the National Institute of Neurological Disorders and Stroke who have discovered that boosting the transport of mitochondria along neuronal axons enhances the ability of mouse nerve cells to repair themselves after injury.

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The truth is out there: Scientists unlock X-Files DNA mystery

x files

x files

Scientists have unlocked a crucial part of the mystery as to how our DNA can replicate and repair itself – something which is essential for all life forms. The new research has revealed how branched DNA molecules are removed from the iconic double-helical structure -a process which scientists have been looking to unlock for over 20 years.

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Zika virus directly infects brain cells and evades immune system detection

zika virus

zika virus

The mosquito-borne Zika virus linked to microcephaly and other neurological problems in newborns of affected mothers directly infects the brain progenitor cells destined to become neurons. The team of researchers used a strain of Zika currently impacting the Americas, and found that the virus infects about 20 percent of cells on average, evades immune system detection, and continues to replicate for weeks.

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New muscular dystrophy drug target identified

DMD

DMD

Scientists have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair. This finding provides a new target for potential drug treatments for the disease, which currently has no cure. Muscular dystrophy (MD) is an inherited genetic condition that gradually causes a weakening of muscles.

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