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Posts tagged “neuroscience

Learning is sneaky

Three years ago this fall I walked into my main-PI’s lab for the first time and I knew nothing about the work we did. I was a mechanical engineer and had machining, solid modeling, and control experience. None of which helped me in my new position. Learning something new is a slow process. The more you learn the more you realize you don’t know anything and it feels like three years later I’m just as clueless as I was when I first set foot into the building. Learning is sneaky that way, you don’t always realize how far you’ve come.

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The start of a busy week

Splitting your time between two labs should be pretty straightforward, on one hand my two PI’s have come to an agreement about how my time should be split and in a 40 hour work week, each should get roughly 20 hours of my time dedicated to the things they are working on. Easy, except it isn’t. Both are used to 40 hours to their lab and I’m not complaining, I enjoy being wanted, but as my Co-PI pointed out I have a lot going on and I need a break. Literally he told me to take a break, it’s bad enough that my Co-PI is telling me to go home.

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My talk is today and you’re all invited!

Okay so I wanted to update everyone on how my first lecture went yesterday since I only had a few short days to throw everything together and it was a mad panic to the end. Unfortunately we cannot go into detail today! That’s because today is my “I’m giving a talk” talk (which I wrote about here). It’s free to watch, my talk is roughly four minutes long and is a nice little rundown of some of the work I do. So today I figure I will go into a bit of detail and should you be so inclined to attend you’ll get the chance to chat with me in person about my work! Yep, I’m breaking anonymity yet again, but it’s for a good reason.

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Depression, a tale of hunger

Let’s pretend you have a pet that is constantly hungry. You can’t leave the house, you can’t sleep, you can’t even take a shower because anytime you want to do something for yourself this monster of a pet just won’t allow it to happen. It’s hungry. It wants to be fed and it wants to be fed NOW. Oh you’re exhausted, feed it. You want to do something for yourself? Too bad, feed it. It’s all consuming, it never sleeps, it never is satisfied, and you cannot get rid of it. Chronic depression is the pet you never asked for that demands your attention all day, every day.

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On designing experiments

After meeting with my Co-PI and discussing the super cool experiment he wants me to do (here) it sounds like I’m in control here. Scary thought, right? This is that whole working WITH my Co-PI and not FOR my Co-PI, he trusts me to make good choices. I mean either way he’s going to need to sign off on it when I finish the design, but it’s kind of interesting to be the one who gets the say in how we do this.

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Surprise teaching, seriously.

Well this is awkward. My main-PI just asked me to teach a course on MATLAB to our new summer interns. Most of them have never used MATLAB before and those that have probably know very little about it. To fix this my main-PI told me that I was going to teach a course on it. At first I thought it was one, but it turns out he want’s four classes (two hours long each) on it. I was trying to have a light summer, but that doesn’t look like it will happen.

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Journal papers update!

Not a typo, journal papers as in multiple. This year I’m planning on submitting three different journal papers. I’ve already submitted two and got feedback on them, so technically resubmit those. The third is still a work in progress and to be honest, there could be a fourth that I submit this year as well. Basically there’s a lot going on and it’s all pretty mindboggling that I can’t seem to get any of this off my plate. It’s a process for sure, but even though I’m still hard at work, there’s been some progress.

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The importance of boundaries

Often times I hear stories about people who feel powerless doing a PhD and I can understand why. You’re given a position with some freedom, certainly more than you had as an undergraduate, but at the same time you have no real power. You’re an adult who is starting a career, but you have very little say in that career. The system is designed in such a way that you need to trust that your PI will take your feelings into consideration, but that doesn’t mean that they have to, are incentivized to, or frankly that they even will.

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Surgical shadow update!

Well I finished my surgical shadow today. Frankly I’m exhausted, maybe I was just too excited, but I got roughly zero sleep last night. That said, it went better than the last shadow where I had just gotten my second dose of vaccine the day before. Now that was not my idea of a fun time! So per the usual I cannot go into the details, but I can talk vaguely about what happened and what’s next.

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Another surgical shadow

Just FYI, I didn’t take this and I’m pretty sure it’s just a stock photo, but it works for the post. I wouldn’t want to cause any privacy issues.

Well it’s officially on the books! Monday (super early) morning I will be shadowing my second surgery. For those new around here this was the first. It was an awesome experience and I’m excited to do it again. Today we’ll talk about why I, as someone who does non-invasive research, is even attending surgeries and what I get out of them. There is an actual practical reason to attend, but it’s also just super interesting!

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The best laid plans…

The full quote is “the best laid plans of mice and men often go awry” and is from a poem, but also inspired the book title, “Of mice and men”

Well this week has been a serious rollercoaster of emotion. There have been incredibly high highs and extremely low lows. It’s so bad I’m not even sure what’s going on at the moment and it’s throwing my entire life into chaos. I wish I were exaggerating, but unfortunately I am not. So what has me so out of sorts? My academic plans are entirely up in the air now. For the next few months (up to 6 months) I will have to sit and wait to figure out what I can do about it. Let’s just start at the beginning.

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Intro to ICA

Independent component analysis, probably not something you hear about all that often unless you’re in a field that uses it. If you’ve found this via google or the such, then you’re probably looking for an explanation on what the heck ICA is and how to use it. Fear not, today we’re going over the why of ICA, why it works, why we use it, and why it isn’t the perfect tool we wish it was. Hint, the reason it isn’t perfect is because of math, stupid math. Quick note, I’ll be focusing on EEG uses for ICA, but there are tons of other applications and this knowledge will still apply to them as well.

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First class of the summer

I’m teaching again! Okay, I didn’t exactly stop, I mentor and do other things, but tomorrow is the first class of the summer that I’m teaching. Which means today I need to finish the slides I’m using, review the materials, and get everything ready so everything will go smoothly. There’s a lot of moving parts that have to happen and while I’m not particularly new to this, it will be the first time teaching the topic. What topic is that? Well…

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Journal problems

I feel like I’m playing the how many journal papers can I have in review at once game and I hate it. Since there’s so much going on I think it would be a good idea to discuss a little bit on what I have up in the air at the moment, why I’m so freaking annoyed about the situation, and what comes next. Most of this is just me being frustrated and venting about the process, but what the hell, sometimes it’s okay to complain. I think that’s pretty much what grad school is anyway, getting better at complaining.

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Surprise summer project!

I’m super excited! My Co-PI sent me an email late yesterday asking me if I had time to help with an experiment. I absolutely love my Co-PI’s lab and all the stuff they do (throw back to this post), so of course I wanted a project! Well I read over the proposal and what he wanted me to do and let’s just say that I am in for a fun summer. I cannot wait to get started, since I can’t go over the details about what I’ll be doing, I think I’ll talk about the consequences.

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On having two PI’s

My two PI’s, a comedy/drama TV show I want to make one day which just happens to be based on my life. Yep, for those who are unaware I have a dual appointment in a hospital where I do a lot of my research. It’s amazing and it really makes me excited to focus more on the clinical side of things, but it means that I have not just one, but two PI’s and that isn’t a bad thing! It’s just a bit of work and can feel like being caught in the middle.

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The start of summer teaching

Today is the start of our labs summer classes. This marks the beginning of roughly 12 weeks worth of lectures on the stuff we do in the lab for our undergrad and high school students. It will be a chance to teach them how to use some of the techniques they will be working with during their summer with us and it will also be a good refresher for everyone in the lab, because we tend to focus on very specific analysis when we do our research it helps teaching each other some of the things we do well.

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A data detective

You did a cool experiment, you have some interesting data, and you found something unexpected! Great, but what does it mean? Sometimes the answer isn’t as straightforward as you may hope. That’s the problem for the day, I found something in my data that makes no sense and the worst part is I have no idea what it means. It’s definitely something, so now I need to go through the steps of making sense of it. That’s the problem with doing something new, you have no frame of reference for the result.

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The first in-person meeting

Well today we met as a lab for the first time since the pandemic hit in person. I wasn’t a fan, still am not a fan, but didn’t get a choice in the matter so I went. Thankfully everyone was masked and agreed that it was probably for the best since in my case specifically, I work with a very vulnerable population. It was nice to see everyone, but it was mostly a waste of time, mostly.

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Meetings and more meetings

Today was going to be about my meeting yesterday with my Co-PI, buuuut it turns out that I have even more news than that! How did that happen? Well I got an email from my main-PI asking me about my plans for the summer, when I wanted to finish the long, horrible, project I’ve been trying to work through, and more importantly, my funding situation. After some emailing back and forth things are looking dare I say good?

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So I shot myself in the foot

Ever say something dumb and immediately regret it? Yeah I made a huge mistake and ended up giving myself a ton of work for no reason. Well there was a reason, it just wasn’t needed. I don’t know why I do this to myself, but the good news is I got the work done. Okay, fine I’ll explain, it’s not a long story, but it is a funny one (at least now that the work is finished). It’s also a good reminder to never do that one again.

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Data mysteries

Data processing, it’s mind numbing sometimes. I guess it depends on the dataset you’re working on, but in this case it’s just a formatting thing. Literally copy, paste, rearrange, things like that. The issue is the volume of data you’re working with. The whole thing can take hours just to get done properly, but with any luck you’ll only have to do it the once. Most of the time I’m not that lucky, the last dataset I worked with for my Co-PI I reformatted five or six different times. While that isn’t the topic of the day, it’s a good way to start the conversation of the day.

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Learning can be painful

Well today was the final lab meeting of the term. While the weekly meetings will (probably) be continuing, it’s still a big deal and could (hopefully) mean the end of my six weeks or so of torment. Normally I give it a few days before I talk about just how badly the meeting went, but this time was different and I’m thankful for it. The difference? My main-PI was out for medical reasons, so we got to talk about the project a little more freely.

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Flexible coding for data visualization

My main-PI has an odd habit of wanting us to edit things as we’re presenting them. I’ve watched this happen and had to do it myself. Suddenly you find yourself editing a paper/grant/etc. and forgetting how to spell your name because you’re so flustered. It isn’t just papers though, it’s our visualizations that we make. He will ask us to go in and change things as they are being shown. This has happened to me several times already and more often than not I’m ready for it. So today I figured I would go over some of the things I do to make sure that I don’t spend the entire time sweating over edits to my code.

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Apparently I’m close?!

We’re talking about it again, the fact that every week for the past 5 weeks now I’ve been given tasks to do and then presenting on them the following week. It’s been… hard. However, my main-PI gave me hope that the end of all this is close, at least that’s the hope. He said I was close, so today we’re going to talk (as usual vaguely) about what I have left to do before this weeks meeting and why I cannot wait to be done with this.

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When you don’t want to say no

In undergrad I had a discussion with my advisor, or rather he was more of a mentor, he wasn’t technically an advisor. It went something like this, I don’t know what to do next because it all seems so interesting. He argued that it was a good problem to have and while I have generally narrowed down my focus (I am doing a PhD after all), I still have an issue with focusing my excitement. It’s like being at Disneyland and trying to force yourself to go on just a single ride your entire trip. I don’t wanna, I want all the knowledge!

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On the prefrontal cortex and abuse

Adulthood is often thought of as the point where you’re done developing. Most states for example don’t allow anyone under 21 to drink because that was where we drew the line, but we allow people as young as 18 (here in the US) to join the military, vote, etc. You may think that this would be roughly where we stop developing and that would explain the somewhat artificial line we’ve drawn. The truth is much stranger than that and when it comes to the brain you don’t develop evenly.

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Journal club

Okay, get this I completely skipped over the fact that my Co-PI started a “journal club” for our little lab. I say little because for the longest time it was just the two of us and the research coordinator (who is amazing by the way!), but now we have not one, but two others in the lab. It’s nice not having to do a lot of extra work, but different topic for another time. We formed a journal club a short 8 weeks ago and every other week one of us sends out a research paper they find interesting about a week prior to our biweekly meetings and then that person presents on it. This week it’s my turn and of course, the universe is against me.

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I’m giving a talk!

Well I slipped through the cracks yet again! It hurts me to admit that I’ve probably earned this one. The 7th annual BRAIN initiative investigators meeting is coming (in June) and I was selected for a Trainee Highlight Award. Is it a big deal? Probably not, but I’ll take a win when I can get it. Today we’re going to dive into what exactly this means for me and why even little victories should be celebrated. Is it a little victory? I mean they did pick me, so what does that say about them?

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Clinical research in a pandemic

Male and female characters scientists or lab attendants working in science laboratory using microscope, lab glassware, vector flat illustration. Scientific research, experiment, science and education.

One of the more interesting things about the pandemic is that everything at the university level shut down. They still send out emails suggesting that everyone wants to go back to in person classes, but they haven’t followed through with that threat. Human participant research has been halted and even though we’re probably going back to “normal” in the fall, right now nothing is happening. That’s at the university level though, clinical research is a different story.

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The long data processing road

Okay I’m taking another break from the “in statistics” posts, at least for today since the next topic is going to be a long multi-day post worth of stuff and I need an easier post for today. I have way too much stuff going on at the moment to organize a long post! In any case, I figure I could give an update to the data I’ve been working with and how that whole mess is going. It’s mind numbing and exhausting work, but not in the way you would think.

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The juggling act

The middle colorful plot, it’s called a spectrogram and if you notice the colorbar to the right has values ranging up to 25,000, that’s not right…

Blogging and coding and writing, oh my! There’s a lot to get done, seems like a running theme around here doesn’t it? If it were possible to clear some of it off my plate it wouldn’t be so bad, but the sad truth is deadlines seem to like to group together and there are quite a few coming up. Most of them are for my class so I can’t really miss those even if I wanted to. My research deadlines I can’t really miss either, not without some consequences anyway. So we’re back to juggling everything, but as we’ve seen in the past, I’m pretty good at this.

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The new to-do list

It’s been busy! So busy I was trying to find time to write while working on the million other things I have going on. Since I have a moment, I thought now would be as good a time as any to go over the big list my main-PI gave me to do before next week. It’s a long, long, long list and as you may expect, he’s pretty far removed from the situation, so I don’t think he realizes how difficult it is to do what he’s asking, but we’re doing any anyway! Thankfully I’ve gotten pretty good at coding, the bad side is that it’s not my code I’m working with, so that’s the start of my struggles.

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Twice the work, half the… fun?

I work with… Braiiiiins!! Well yesterday I touched on an experiment I did waaaay back in October-ish of last year! With the way things are going it feels like five years not 5 months, but what can you do? My main-PI has started to not so gently or subtly push me to process the data to his satisfaction and start working on the publication of the results. There’s been a lot going on that has pulled me away from the project, from the end of December to the middle of February I was working on grants, but now there isn’t a whole lot stopping me from working on this project almost exclusively… if you don’t include the other grant I’m writing and the fellowship I’m supposed to apply for.

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A roadblock

I haven’t spoken with my Co-PI about this yet because I’m angry. Like fist balled, white knuckled, want to scream into some endless void angry. This was not the post for today, but I’ve learned a long time ago that I should get things out instead of bottling it up and letting it eat me alive. It’s the reason I’m still here today and one minor step to my success in not falling into the abyss that is depression. I am angry and I need to chose my next words carefully, because as you’ll see, I have no power here.

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A meeting with my two PI’s

Yeah it feels pretty dangerous…

If I could make a comedy TV show about my life, I would call it my two PI’s and I would get into hilarious situations while trying to make both of them happy. Mostly you would see me get a lack of sleep and sort of feel like I’m running on a treadmill, going as fast as I can, but getting nowhere. It’s not all bad and I respect my two PI’s, but there’s a saying about having too many hands in the cookie jar and sometimes it feels like that’s what is happening. It’s a lot like the old game “telephone” where I’m given information to pass along between the two, so we’re all going to meet… *cue dramatic music*

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A look ahead

With the weather trying to kill everyone, the pandemic trying to kill everyone, and just life in general I feel like things are moving…. slooooow. I have a weekly meeting with my main-PI who reminded me that I’m behind and while he agreed it was probably due in part to the pandemic, it’s time to try and catch up. There is a lot going externally and internally, but I’m hoping that by covering a few things here I will have a nice little list I can refer back on and keep me on track. That’s the idea anyway.

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What is good outreach?

Yet another outreach event in the books! I have two more events this week and I believe that’s the last for my skype a scientist commitment. Since this term I was assigned classes practically all at once, I may re-volunteer to get a few extra classes in this term. Normally requests for my specific field don’t happen, but they’ve become more frequent, which is interesting to see because biomedical engineering, or my subset neuroengineering, isn’t a widely known field, but it is growing. All this recent outreach has gotten me thinking about what makes a good presentation, so let’s talk about it.

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Experiment Results

It’s been a crazy week, more so than usual! The R21 grant I’m writing is due to my Co-PI today, it’s our self imposed deadline. It’s not THE deadline, but it might as well be in my mind. I’ve processed most of the data from the experiments and yesterday I said we would talk about the result from finding an error in my code. Well let’s talk about it!

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The last experiment!

Today’s the day! It’s the last experiment for our R21 grant, we had our first set of experiments last week and today we’re completing the final experiment today. Hopefully we’ll have some good results for our grant, I got done processing some data last night and if I didn’t make an error the results were slightly underwhelming, but we’ll have to see I guess. There’s still a lot of things I need to check so I’m not too worried, okay slightly (very) worried…

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A new science outreach project

Today we’re making a movie! Okay, it’s not a movie persay, it’s a virtual outreach project I’ve been tasked with by my main-PI. Unlike most outreach I do, this is going to take some planning, a bit of script writing, a easy to do exercise that can be followed at home, and lastly a little write up on everything going on. So when I say some planning, I mean a LOT of planning!

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Experiments update!

Yes the data always look like a bunch of random squiggles, that’s why it takes forever to make sense of it.

Well a lot has happened this week, maybe not the most interesting of things for my readers, but this week has definitely kept me on my toes. Today we’re going to have to talk in circles because I can’t give away my “super secret” technique I’m researching, but I also have news about that technique. It’s all very hush, hush, top secret, would have to kill you if I told you type stuff for now, but that doesn’t mean we can’t talk about how the experiments I’m doing went!

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Second grant experiment

Data processing…. now in parallel!

Ever have one of those days that is so packed full of stuff to do you don’t think you’ll get a chance to eat? Well today is one of those days for me, I’ll be busy from morning to evening today between my experiment and class I don’t get a break! Since that’s the case, I think we should look at what’s on the agenda for the day in a bit more detail and how I plan on managing my time so that (hopefully) I won’t be late for anything.

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More on grant writing

Got the first round of edits back from my Co-PI on the R21 grant I’m writing. At first they didn’t look too bad, but it turns out he reworded quite a bit. Not that big of a deal honestly, but he did suggest that it was close to perfect, so I would hate to see what “not close” looks like. Today I figure we can discuss what I have left, why there’s a rush to get all this done, and why the heck I’m doing soooooo much writing!

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More experiments!

*Cue mad scientist laugh* It’s alive!!! ALLLLIIIIVVVEEE!! No, I’m not reanimating corpses, I just work with human participants so if they weren’t alive it would be awkward. I mean really, really awkward. Thankfully since they are non-invasive experiments the risk of serious injury is almost zero. All this build up to say I’ve got some new experiments starting today, as in MY experiments! *Cue second mad scientist laugh*

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The first week of classes

When you start a PhD program, or a Masters program (I have a BS and MS so I can speak to this) things aren’t as structured as they are in undergrad. Not that undergrad programs aren’t hard or not hectic, it’s just that there are scheduled times for everything so you know when and where you will have work. It’s a lot like highschool in that respect, you get homework, but there’s a clear end to it. Not so much in grad school, your homework takes a year or even years (for a PhD) to finish. Still, it’s the first week of school, so things change, if only slightly.

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My first surgical shadow

With all the COVID excitement going on around here, I haven’t had the chance to share my experience about one of the coolest things I’ve had the chance to do thus far in my career! Since starting my PhD I feel like I’ve had all sorts of interesting experiences and while they haven’t helped me publish anything, I’ve learned a lot. Making a jump across fields like I did (design engineering to neural engineering) has had a steep learning curve from the start, but almost three years in and I’m feeling good about the decision.

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I’m going into surgery… sort of!

Okay well this came out of left field, or rather happened faster than I thought it would. My Co-PI and I had discussed just last week seeing some of how the more clinical stuff gets done in terms of electrophysiology and invasive monitoring. He suggested I shadow some of the doctors while they are performing surgery to see how they do the things they do and now I’m about to get the chance to do just that. Yeah, that’s a lot of doing.

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First grant meeting

Time to put the fun in funding?

Well it’s been a weird couple of days and by weird I mean, WTF?! For that reason let’s shift slightly back into the school aspect of things. I had my first meeting with my Co-PI to discuss the grant writing I’m going to be doing and what we want to focus on. Turns out there’s a lot going on and not all of it had to do with the grant, but it was a good meeting and I’m excited to get started.

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New year, new grant

It’s all connected somehow… I just know it.

Nope, still on vacation… I tell myself as I make arrangements to meet with my Co-PI. This is important though and unlike some of the other projects it has a firm deadline. That’s right, I’m writing a grant. No this isn’t an update to the last one I wrote, this is a whole new one. How did I end up in this position? Who knows, but I’ve been trying to figure it out since it happened. Let’s discuss, shall we?

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