Schizophrenic Noise and Schizophrenic Voices
Hear that voice? What, is there more than one? Is this real, or fake? How do you know? That is how schizophrenia works: auditory hallucinations, confusion, inability to tell what is real and what is not. Schizophrenia isn’t something a person can simply ignore. You can’t get rid of that voice, or even the voices on your own. But what causes this problem? That was the question researchers wanted to tackle.
New ways to test for Alzheimers
Accurately diagnosing alzheimer’s is not an easy thing to do. In fact most of the time people aren’t diagnosed until very late in the progression of the disease, long after serious damage to the brain has been done. Biological markers of Alzheimer’s disease may be able to detect it at an earlier stage. For example, using brain PET imaging in conjunction with a specialized chemical that binds to beta-amyloid protein, the buildup of the protein as plaques in the brain can be revealed years before symptoms appear. But as with anything that requires any sort of imaging techniques, these scans can be expensive and are not available everywhere. That is all about to change thanks to four new studies that aim to help offer multiple ways to test for alzheimers much earlier than we can currently test.
Infant once thought Cured of HIV tests Positive
I hate doing sad posts, it’s not my thing. But this is a big deal so I thought I would share it, the child known as the “Mississippi baby” — whom for those of you who don’t know is an infant whom had been treated directly after birth and was cured of HIV which was reported as a case study of a prolonged remission of HIV infection in The New England Journal of Medicine last fall — now has detectable levels of HIV. Even after more than two years of not taking antiretroviral therapy without evidence of virus, according to the pediatric HIV specialist and researchers involved in the case.
Antioxidants can Accelerate Cancer, ya really!
Oh rly?
Oxidative stress on the body caused by free radicals, billed as a bad thing. Fruits, veggies and just about anything with the word healthy in the title is “jam packed” with antioxidants. But they don’t provide the health benefit the are billed to have, that’s because oxidative stress isn’t a bad thing for the body in some cases. Now researchers have shown that antioxidants can accelerate cancer and we also know why.
Lose Weight, Live Longer. Simple, Right?
It’s funny because it’s true.
Suprise! Really this shouldn’t come as a shock, but adults with extreme obesity have increased risks of dying at a younger age from cancer and other complications like stroke, diabetes, heart disease, and kidney and liver diseases, according to results of an analysis of data pooled from 20 large studies of people from three countries. The study found that people with class III obesity [or extreme, as defined as a BMI of greater than 40] had a dramatic reduction in life expectancy compared with people of normal weight.
Staying up late? You’re going Crazy
All night cram sessions, anyone in college has probably had more than just a few of these [okay maybe only if you are a procrastinator like me]. If you have done anything like that, well then you know how weird you start to feel. Well researchers have now shown that with a “mere” twenty-four hours of sleep deprivation can lead to conditions in healthy persons similar to the symptoms of schizophrenia. The team points out that this effect should be investigated more closely in persons who have to work at night [as anyone who works nights knows how hard that can be on a sleep schedule]. They also recommend that sleep deprivation may serve as a model system for the development of drugs to treat psychosis.
Breast Cancer… and Cholesterol?!
Cholesterol, it’s bad for the heart. We know LDL bad, HDL good, eat healthier or ruin your arteries. I’m sure most of us have seen the public service announcements [at least here in the states]. But if that wasn’t a good enough reason for people to watch their cholesterol then how about cancer?An association between high blood cholesterol and breast cancer has been found in a study of more than 1 million patients over a 14 year time period in the UK.
Why you Should Not Fear Testosterone Therapy
Testosterone, to some it’s a bad word, bringing crazy images like “roid rage” and the like. To others with more than just a pop culture understanding it is a lifesaver. In fact, prescriptions for older men in the United States have increased more than three-fold over the past decade. Unfortunately recent studies linking testosterone use with increased risk of heart attack and stroke have caused widespread concern among patients and their families. The validity of those studies [and their methods] have been in question and [yet another] new study aims to help end the confusion. The new U.S.-based study of more than 25,000 older men shows that testosterone therapy does not increase men’s risk for heart attack.
The study examined 25,420 Medicare beneficiaries 66 years or older treated with testosterone for up to eight years. Studies like this one are tough to do so the researchers used public health data to wade through the claims.
St. Johns Wort and the Dangers of “Alternative” Medicine
Grapefruit juice, I hate the stuff. But did you know that if you drink as little as 8 oz. of it when you take certain medications it could dramatically increase the effectiveness of the medicine? Sounds like a great thing, sure, until you realize that the dose of medication you are taking is specific to you and that increasing it can have serious side effects and in some cases cause death. This discovery led to the inclusion on the labels of certain medications to be cautions about grapefruit juice [and grapefruit] consumption.
Noninvasive Brain Control via Jaws!
Mind control, we’ve seen several semi [see very] invasive ways to make it happen here from the Labs. Now those crazy scientists from MIT have developed a technique that allows researchers to enable neurons to be silenced noninvasively, using a light source outside the skull. All using a protein known as Jaws.
Optogenetics [a technology that allows scientists to control brain activity by shining light on neurons] uses light-sensitive proteins that can suppress or stimulate electrical signals within cells. This technique is very invasive though because it requires a light source to be implanted in the brain, where it can reach the cells to be controlled.
Anti-aging drug has a Catch… but not for Long
Dietary restriction holds the key to longevity. It’s no secret that as you drastically reduce calories, your metabolism will slow down with it [ask anyone who’s tried to crash diet about that one]. Science has been trying to crack that egg for awhile now and because of that, it is the most researched method for slowing down the aging process. That was why researchers were so excited to find that a drug — rapamycin — appears to mimic that anti-aging effect.
Rapamycin, an antibiotic and immunosuppressant approved for medical use about 15 years ago, has drawn extensive interest for its apparent ability — at least in laboratory animal tests — to emulate the ability of dietary restriction in helping animals to live both longer and healthier. If the name sounds familiar that is because rapamycin is primarily used as an immunosuppressant — to help prevent rejection — specifically for people who have had organ transplants.
Autism and Pesticides: What, too obvious?
There have been a few different things linked to children who fall under the Autism Spectrum Disorder. A combination of genetic and environmental factors, along with complications during pregnancy have been associated with the diagnoses. And a new study aims to strengthen the link between prenatal exposure to pesticides and autism [Please hold your collective duh’s until the end]. The large, multi-site California-based study examined associations between specific classes of pesticides, including organophosphates, pyrethroids and carbamates, applied during the study participants’ pregnancies and later diagnoses of autism and developmental delay in their offspring.
To Lose the Weight, Feel the… freezer burn?
Are you so fat you can’t see your toes? Have you forgotten what toes even look like? Have you been mistaken for the infamous “Kool-aid man”? Want to shed the pounds easier than taking off your shirt? Well too bad, that is science fiction and the stuff of horrid marketing ploys and this my friends is a science website. Losing weight is hard, I’ve written several articles on it in fact. Nothing is going to be more effective at weight loss than a sensible diet, a calorie deficit and maybe some insoluble fiber that I mentioned in the very first article I’ve written.
A new companion study to this post, which I wrote not long ago not only confirms that original studies findings, but also gives insight into another factor for the mounting obesity epidemic.
Warning: Serious Side Effects may be Overstated
Black box warnings, I’m all too familiar with them. A quick look in the medicine cabinet and you would see why. In fact I’m surprised the door shuts some days. No, I’m not a druggy, by any means. I have problems and frankly who doesn’t? These days, like millions of Americans I find some sort of comfort in pill form. It’s not perfect, but most days you wouldn’t know I had my own problems. It’s unfortunate then that the black box warning labels we see on just about every type of antidepressant may be doing more harm than good.
New and Exciting discoveries about Autism
Vaccines don’t cause autism. One more time, all together now, vaccines do not cause autism. Thankfully science understands that and is moving in on the actual cause for it. A combination of new studies not only shows a link between a particular gene and autistic disabilities [since it’s an autistic spectrum], but the second study offers a potential new pathway for treatment of the disorders.
Autistic-like behaviors and decreased cognitive ability may be associated with the disruption of a particular gene, in this case the APC gene [Adenomatous Polyposis Coli]. The connection was made when Tufts researchers deleted the gene from select neurons in the developing mouse brain. The mice developed all the autistic characteristics, such as reduced social behavior, increased repetitive behavior, and impaired learning and memory formation. This study is the first to look at how the loss of APC from nerve cells in the forebrain affects brain development, learning, and behavior.
Does the Bionic Man dream of an Electric Pancreas?
Diabetes can be torture; between the pokes and pins, the special diet, and constant monitoring, diabetes can be a special brand of hell [which is right next to the people who talk in movies]. Insulin pumps can help ease that pain, but science has introduced a piece of technology that would make the bionic man proud.
Lab Made Flu Coming to a Outbreak Near You!
Spanish Flu outbreak of 1918
Forgive the alarmist title, I had to do it. Researchers have created a genetically engineered version of the flu, similar to the spanish flu that killed roughly 50 million people in 1918. Don’t worry, it’s not as bad as it sounds, that is until someone sneezes and drops the vial… but what are the odds that would… umm… happen.
Truthfully there is already a war coming. If anyone remembers the swine flu outbreak a few years back, you know what I am talking about — for those of you who had it, including yours truly, you know how horrible it can be. Swine flu or H1N1 was a supercharged flu that was 95% or so genetically different from the flu we have typically seen. This lead to all sorts of fun and horrid complications from the outbreak due to the fact it was something the body had never really seen before.
Lies the Labels Told Me: Beware Food Buzzwords
Organic, All natural, and packed full of antioxidants; sounds healthy, doesn’t it? Unsurprisingly however, if something is trying to tout how healthy it is, it probably isn’t. Of course all those buzzwords have to mean something… don’t they?
According to a new research study conducted by scholars at the University of Houston, health-related buzzwords, such as “antioxidant,” “gluten-free” and “whole grain,” lull consumers into thinking packaged food products labeled with those words are healthier than they actually are.
New Obesity drugs: Coming Soon to a Store Near You!
Afraid to go into public because you think those double doors might be a little narrow for you? Are you pretty sure you have feet, even though you haven’t seen them for awhile now? Did you recently find something you think may have been a twinkie at one point in your folds? If you answered yes to any of these questions, then science might be able to help.
Believe it or not weight gain is complex –or at least the biological aspect of it– for example hormones control our appetite and even the uptake of food. In recent years, science has taken on the seemingly insurmountable quest of investigating these physiological functions and finding a medical way to fight the ever growing obesity epidemic.
Alcohol Abuse and Combat in the Military
It’s no secret, I’m a proud Marine and combat veteran. So while searching for the latest and greatest science to write about I was surprised to come across a study on combat and alcohol abuse. Thinking I already knew the answer I almost didn’t bother to read it — when I did, the results were a little surprising and I wanted to share them.
[Creepy] Plasmids and Antibiotic Resistance
If the title didn’t give it away, plasmids are creepy. For those of you who are confused by that statement let’s cover what a plasmid is exactly. Plasmids are very short circular pieces of DNA that are like little virus’. What makes the little buggers creepy is that they aren’t technically living, but possess all the qualities that would make you think otherwise.
Eternal Sunshine of the Spotless Mind?
A frame from Eternal Sunshine of the Spotless Mind. What if it was more than just a movie…
Much like this posts namesake, the movie Eternal Sunshine of the Spotless Mind asked what if you could erase memories? Want to forget your ex, no problem. Better yet, what PTSD? I’m sure that all of us can think of at least one or two things — be it embarrassing, or scary — that we would like to forget.
Or conversely, maybe there is something forgotten, something you would give anything to remember — like a loved one or a relative — locked away deep in your brain. Thanks to new advancements in neuroscience, it’s technology that is not just in the movies anymore.
Diet Soda and Weight Loss
A quick google for the term diet soda will show you a wide range of “health issues” related to drinking diet drinks. But thankfully a new study sheds light on the truth behind the diet soda and weight loss myth.
No pain, no [weight] gain?!
Pain is… well a pain. As it turns out pain does more than just hurt. A study just released shows that chronic pain not only lowers life expectancy, but can also slow the metabolism.
How I Learned to Stop Worrying and Love the Fluoride
“Have you ever seen a commie with a glass of water?”
In the 1964 Stanley Kubrick film, Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb, it’s a question that leads to a conspiratorial rant about the dangers of water fluoridation; one you might be likely to hear today in fact.
It is 50 years after the making of the movie and water fluoridation still seems to be a hot button topic that draws nuts from just about all walks of life. Unfortunately, as with most pseudoscience, the controversy is manufactured and as a consequence, misinformation is spread.
Snail Venom and Pain Relief
There is no pain like nerve pain. Unfortunately my sister and me both know all too well how bad pain can actually get, her especially. After desperately trying everything from morphine derivatives to a combination of calcium and sodium channel blockers we had exhausted all attempts at keeping her pain at bay. That is where the story would’ve ended too, if it wasn’t for the sea snails.
New Study Explains why MS Affects more Women
MS affects women almost four times more often than it affects men. The reasons are unclear, but a new study is the first to associate a sex difference in the brain with MS. The newly identified difference between the brains of women and men with multiple sclerosis (MS) offer not only insight into why, but also may offer a course of treatment.
Looking at mice and people that have MS, the researchers found that females susceptible to MS produce higher levels of a blood vessel receptor protein [S1PR2]. than males and that the protein is present at even higher levels in the brain areas that MS typically damages.
Turning Back the Clock: Arteries
In what appears to be Fountain of Youth month here at Lunatic Laboratories, we have yet another way to turn back the clock, this time specifically for your arteries — at least that’s what University of Colorado Boulder are hoping with the new study they recently released.
When researchers gave mice [the human age equivalent of 70 to 80 year olds] water containing a specific antioxidant [MitoQ] for four weeks, they found that the arteries of those mice performed like arteries from mice with an equivalent human age of just 25 to 35 years.
Testosterone and your Heart: Don’t believe the hype
Testosterone, the “big T”, you can’t turn on the TV without someone talking about it. In fact, despite the bad [and almost completely false] press about the effects of testosterone, the amount of prescriptions in the US has tripled since 2001. Rightfully so, anyone on testosterone therapy will tell you how incredible the effects can be on day to day life.
Unfortunately testosterone therapy has it’s own smear campaign [analogous to the anti vaccination movement], surprising considering the number of people on TRT [Testosterone Replacement Therapy] I know. People throw around terms like roid rage [which is not real] when TRT is brought up, or depression, which as the evidence shows is the exact opposite of what TRT does [can you see my frustration yet?].
Another Road to the Fountain of Youth
Photo credit goes to: Robert F. Bukaty, AP
Recently on Lunatic Laboratories we reported on a new path to the fountain of youth that had been found [at least for mice]. Well today, we are happy to announce that another road to the fountain of youth has been potentially discovered. This time the discovery was made by Harvard Stem Cell Institute [HSCI] and Stanford researchers.
Being the over achievers they are, they released not one, not two, but three studies showing that substances in the blood of young mice rejuvenate the brain and muscles of aging mice. Two of those three studies, by Harvard researchers were released early online just yesterday, but won’t be published until later this week in the journal Science. The two are similar to the third [albeit not connected], Stanford study that suggests the same reversal of aging also happens to their hearts.
The Fountain of Youth [Coming to a store near you]
The fountain of youth, as it turns out, isn’t so much a fountain, it’s a new drug. There has been countless dollars thrown at anti-aging research, some producing better results than others. So when scientists at northwestern medicine in collaboration with Tohoku University in Japan, released a new study I am sure there was more than one happy person seeing the results.
The team, building on previous research, have managed to extend the life of accelerated aging mice more than four times longer than the control group. All thanks to an experimental drug — not only did it extend the life, it also protected the lungs and cardiovascular system from aging.
Could a Vaccine for Cancer be a Reality?
How do you take out an unstoppable enemy? You don’t take the enemy head on, you take out the supply lines and the rest will take care of itself. This is not a new idea, but this not so new approach to war is being taken to an enemy on a new battlefield, your body.
Cancer in most cases can be an unstoppable force, collateral damage from chemotherapy can be, and in most cases is unacceptable. That was the thinking from a group of researchers from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania. Their idea, to attack the supply lines instead of the enemy directly.
Five [Medical] lies the TV told me
Fad diets, miracle weight loss super foods, and vaccines! Oh my! We live in the information age, a time where webMD will tell me what kind of cancer I am suffering from today and Dr. Oz will be more than happy to give me advice on the 5 superfoods I should include in my diet so I can live to see a healthy 160. (more…)
Trauma Follows Generations
The consequences of traumatic experiences can be passed on from one generation to the next. (Credit: Isabelle Mansuy / UZH / ETH Zurich)
Did you serve in the military? Maybe you witnessed something traumatic at home, or you had a bad accident. It turns out that if it is extremely traumatic and sticks with you, chances are it will get passed on to your children. The findings come from a new study from the University of Zurich and ETH Zurich and they even have some ideas as to why it gets passed on.
More BIG News for Spinal Cord Injuries
Photo credit goes to: University of Louisville. This photo shows the four participants in the study.
It seems like lately we have been reporting left and right about people suffering from paralysis, and for good reason! Today I’m happy to report even more new research that offers hope for people suffering from spinal cord injury.
In a new study published in Brain [a journal of neurology] researchers used adult patients who suffered different spinal cord injuries. Two had feeling in the extremities, but could not move them, while the other two had neither feeling nor could they move their extremities.
Zombie Cancer Cells Return from the Dead
Zombies, they are the stuff of movies. But an interesting new study by the University of Colorado Cancer Center shows that sometimes reality mirrors fantasy. The study shows that cancer cells will partially eat themselves in times of distress just to come back to life and divide later on.
Autophagy [from the Greek “to eat oneself”] is a process in which proteins, or other surplus materials in the cell that are not explicitly needed for cellular function are cannibalized in times of stress. What was surprising, in this study we see this process used as a method to survive chemotherapy.
Scientists cure Muscle Paralysis in Mice
Photo credit: John Carnett/Popular Science – Optogenetics, tested in rodents, can control electrical activity in a few carefully selected neurons.
Searching for a new way to cure paralysis, a team of scientist has come up with a remarkable and off the wall idea. This discovery comes out of the labs at the University College London. The team, lead by Linda Greensmith, used stem cells and optogenetics to control leg muscles in mice and completely circumvent the nervous system in the process.
For those of you who are not familiar with Optogenetics [and really, why would you be familiar with it?] here is a overly simple rundown of what we are talking about.
Did you hear the one about Vaccinations?
So a lawyer walks into a Doctors office and offers the Doctor large amounts of money if he can come up with a link between the MMR vaccine and some other problem. Not a very good start to a joke, I know, and if you are looking for a punch line there isn’t one.
Unfortunately this isn’t a joke, it is exactly how the vaccination controversy got started. The only punch line here is children catching preventable diseases and I don’t think anyone is laughing.
Just how did one man single handedly cause so many problems?
Orphan Deseases- A Silent Suffering
Cancer is sexy, it’s hip, it’s in, it’s news. All types of cancer, think of a cancer organization; I bet you can. Rightly so since cancer sucks, a cure should be found and we should shout at the top of our lungs that there are people suffering.
There is a beautiful sense of cooperation and unity when you can get a group of people together, like people suffering from cancer and start turning the large wheels of progress to find a way to cure something so dynamic.
[Not so] Big News for Stem Cells
Ever hear if it is too good to be true, then it probably it probably is? Well that seems to be the case for the not so latest news for stem cell research.
Just weeks ago, the science world was buzzing when Japanese scientists announced that it had discovered a novel way to produce stem cells that was free of controversy, cheaper than traditional methods and simple.
Monkey Mind Control
Monkeying around…
What does a rhesus monkey and a the Blockbuster Hollywood film Avatar have in common?
They both use mind control to operate an ‘Avatar’.
Researchers at Massachusetts General Hospital placed a neural implant on the ‘master’ monkey that could monitor up to 100 neurons, this allowed the ‘master’ money to control a second ‘avatar’ monkey.
To test this. they trained the ‘master’ monkey to use a joystick and find a target on the screen.
Prosthetic hand gives amputee feeling again
![Amputee Dennis Aabo Sorensen tests the prosthetic hand in Rome last year. Photo credit [and caption] goes to the independent](https://loonylabs.org/wp-content/uploads/2014/02/amputee.png?w=590)
Amputee Dennis Aabo Sorensen tests the prosthetic hand in Rome last year. Photo credit [and caption] goes to the independent
Hook or hand?
Those are your choices, do you want a fake non-movable plastic hand, or would you prefer the hook? At that point you are probably wondering why they are now making smartphone watches, but you are stuck getting [almost] the same technology that was used during the civil war.
Lunatic Laboratories 