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Day 224: Review – Cortical and Subcortical Effects of Transcutaneous Spinal Cord Stimulation

Figure 1 of the paper showing the experimental set-up and the type of pulse used for stimulation
Figure 1 of the paper showing the experimental set-up and the type of pulse used for stimulation

Experimental set-up. (A) Participants were comfortably seated in a customized chair during transcutaneous electrical spinal stimulation (TESS) or sham-TESS for 20 min. TESS was delivered using a surface electrode on the back of the neck between C5–C6 spinous processes segments (cathode) and a surface electrode in each anterior crest of the hip bone (anode) using a custom made 5 channel stimulator (BioStim5, Cozyma). Electrophysiological and behavioral outcomes were tested before (Pre) and immediately after, 15, 30, 45, 60 and 75 min after the end of the stimulation or sham stimulation period. (B) Schematic representation of the type of current used during TESS. We used 5 biphasic pulses at 5kHz with each biphasic pulse lasting for 200us. The middle scheme shows the blocks of 5 biphasic pulses passed at a 30Hz frequency. Lower part of the schematic shows the number of pulses delivered in one second.

Well it’s been two weeks since the last critical review so it’s that time again. As usual, my PI gets a copy and so do all of you. Since I’ve done several of these now (this is number six) I have a category just for these reviews called critical reviews. This is a really new study which tries to help tease apart what we are actually stimulating when we apply transcutaneous spinal stimulation. I think it’s a super interesting paper and I hope you do as well.

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Day 210: Review – Cervical trans-spinal direct current stimulation: a modelling-experimental approach

Cervical trans-spinal direct current stimulation - Fig. 3
Cervical trans-spinal direct current stimulation - Fig. 3

Average magnitude of the E-field and average amplitude of its components in the spinal-WM in all montages along the z axis. Position of spinal segments is marked on the grey vertical bar, electrodes are represented by vertical bars and active connectors are marked with letter “A”. Volume plots of the E-field magnitude in cervico-thoracic spinal-WM, brainstem and cerebellum are represented at the right of the average distribution in each montage, with the corresponding colour scales

I lied! I did know what today was going to be on, it’s the fifth critical review paper. Since my PI gets a copy, so do you! To be honest, I need to create a category for these reviews (Update: I did make a category, Critical reviews), but for now, my first looking at elbow spinal stretch reflexes is here. My second where I review modulating spinal cord excitability with a static magnetic field here. The third where I review modulating the H-reflex while walking in spinal cord injury populations. Lastly, my fourth on Motoneuron excitability during voluntary muscle activity in a spinal cord injury population  can be found here. That said, let’s take a look at my latest review.

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Day 196: Review – Changes in Motoneuron Excitability during Voluntary Muscle Activity in Humans with Spinal Cord Injury

Figure 1
Figure 1

Figure 1. Experimental setup. A, Schematic representation of the hand showing the ulnar nerve and F-waves recorded from the first dorsal interosseous (FDI) muscle. B, On the left side, schematic representation of the head showing the electrodes placed at the cervicomedullary junction and on the right side a raw trace showing a cervicomedullary motor evoked potential (CMEP). C, A cartoon showing the concept of the visual feedback. Individuals were tested at rest (left single horizontal line) and during 5% (middle double horizontal lines) and 30% (right double horizontal lines) of maximal voluntary contraction (MVC).

A little detour from our spinal cord series for my fourth critical review paper. As usual, my PI get a copy and so do all of you! You can read my first looking at elbow spinal stretch reflexes here. My second where I review modulating spinal cord excitability with a static magnetic field here. Or the third where I review modulating the H-reflex while walking in spinal cord injury populations. Today is an interesting paper on motoneuron excitability while walking in spinal cord injury populations. It’s a really cool paper, so here’s my review.

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Day 182: Review – Modulation of soleus stretch reflexes during walking in people with chronic incomplete spinal cord injury

Fig2

Figure 2 of the paper showing examples of the soleus H-reflex (labeled H) during standing  and during different phases of walking in a participant without known neurological injuries (top) and in a participant with chronic incomplete SCI (bottom).

Today is my third attempt at a critical review paper. Since my PI gets a copy, so do all of you! You can read my first looking at elbow spinal stretch reflexes here. Or my second where I review modulating spinal cord excitability with a static magnetic field here. Today is an interesting paper on soleus stretch reflex and H-reflex. I really appreciate the methodology the researchers used and they did an excellent job of highlighting the limitations to the study, which is always important. Per the usual disclaimer, this is my third critical review, so you can take my opinion n the methodology and findings how you will. (more…)


Day 177: Know your spinal cord – Brown-Sequard Syndrome

vintage spinal cord anatomy art

We’ve made it to day twenty in our little series on knowing your spinal cord. As always, you can find each and every post in this series through our neuroanatomy category. Since we’ve covered all the major neuroanatomy, the latest posts have been on spinal cord diseases and disorders. That said, today we’re covering Brown-Sequard syndrome, so let’s take a look at what this is.

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Day 176: Know your spinal cord – Spina bifida

spinal dissection

This is day nineteen of knowing your spinal cord! We covered all the big neuroanatomy and while we may go back and cover some of the minor things, we’re in the middle of spinal deformities. For those just starting, we have a neuroanatomy category to make it easy to find these posts. For everyone else, today we’re talking about spina bifida.

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Day 175: Know your spinal cord – Diastematomyelia

diastematomyelia drawing

Diastematomyelia, a complicated name for a split spinal cord.

Day eighteen! Almost three weeks worth of fun spinal knowledge. For those tuning in, we have a neuroanatomy category just for these posts. Since we’ve covered most of the anatomy portion of the spinal cord, we’ve just started covering spinal disorders. If you’re here you’re probably wondering what diastematomyelia is, so let’s get started!

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Day 174: Know your spinal cord – The tethered spinal cord

brain and spinal cord

This has been a fun series of posts and today is day seventeen! As usual, you can check out all of our posts under the neuroanatomy category. I’ve got some good news and some bad news. The good news is we’re still going! The bad news is we’ve pretty much covered the anatomy. So for the next few posts, we will look at some issues the spinal cord may have. First up, let’s talk about a tethered spinal cord!

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Day 173: Know your spinal cord – The meninges

cross section of spinal cord

Day sixteen of knowing your spinal cord! So many posts, much knowledge! For those who are just finding us, we have a whole neuroanatomy category dedicated to these posts. If you want to take it from the top (literally) you should start with the medullary pyramids post. If you’ve been following along or only interested in this particular topic today we are covering the meninges and you’ll learn my really dumb way for remembering them, so let’s get started.

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Day 172: Know your spinal cord – The lumbar cistern and cerebrospinal fluid

Spinal anatomy

We are well on our way to finishing up the know your spinal cord series that I am doing. Today is day fifteen and as usual if you’re just tuning in we have a whole neuroanatomy category dedicated to these posts for you to check out organized in reverse chronological order. If you want to start at the beginning, that would be the medullary pyramids. Today we are at the other end of the cord, this is the lumbar cistern!

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Day 171: Know your spinal cord – The cauda equina

spinal cord and brain

Here we are at day fourteen of knowing your spinal cord. By now you’re all experts on the spinal cord and I’m not even sure what I’m doing here. For those just joining us, we have a neuroanatomy category with all the posts so you don’t have to dig for them. If you want to start at the beginning, that would be the medullary pyramids. For the rest of you this is the end, not the end of the posts because we have a lot more to cover, but the end of the spinal cord. Let’s talk the cauda equina!

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Day 170: Know your spinal cord – The spinal cord enlargements

Mitochondria in a spinal cord section

Mitochondria in a section of spinal cord

Here we are at day thirteen of knowing your spinal cord! As always, we have a whole special category for these posts called neuroanatomy and if you’re not after a specific topic, I recommend starting at the medullary pyramids. Today’s post is about something important that we haven’t touched on very much, the cervical and lumbar enlargements of the spinal cord, so let’s get started.

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Day 169: Know your spinal cord – The central pattern generator

V0008396 Brain and spinal cord: dissection, back view. Coloured line

Day (or really post) twelve on knowing your spinal cord. We have a whole category for the posts, neuroanatomy. Today we are going to talk about the curious case of the central pattern generators (CPG’s). Unfortunately, we cannot talk about them without talking about the experiments that found them, meaning we will be covering animal studies. In particular, some animal studies that might not sit well with some people. I attempted to be general where I can, just know that it is coming.

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Day 168: Review – Static magnetic field stimulation applied over the cervical spinal cord can decrease corticospinal excitability in finger muscle

Fig1

Figure 1 of the paper showing how the intervention was applied to the spinal cord

As mentioned in yesterday’s post, this is my second critical review paper. You can read my first looking at spinal reflexes here. Today we are looking at a novel way to modulate spinal cord excitability. Overall I find the paper very interesting. Although the authors performed a limited experiment and no follow up (as of now) has been done, it still looks very promising and would provide a new way to explore the circuitry of the spinal cord. This is my second attempt at a “critical review” so you can take my opinion on the methodology and findings how you will.

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Day 167: Know your spinal cord – The reflex pathways

Gold leaf spinal cord art by Greg Dunn design
Gold leaf spinal cord art by Greg Dunn design

Beautiful spinal cord art, used with permission by Greg Dunn design.

Day eleven, we’ve almost spent two weeks covering your spinal cord! Tomorrow we will take a brief break as every two weeks I have a review paper due to my PI in the spinal cord feild, so tomorrow I will share it with all of you as well. For today, remember we have a neuroanatomy category with all of the posts we’ve done. If you’re new I would suggest you start with the medullary pyramids post and work forward, for the rest of you or those of you who are only interested in reflexes, let’s talk about some legos.

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Day 166: Know your spinal cord – The spinocerebellar tract

Spinal cord section by Ramon y Cajal, a Spanish neuroscientist
Spinal cord section by Ramon y Cajal

Drawing of a spinal cord cross section by Ramon y Cajal, a famous Spanish neuroscientist.

Here we are on day ten of knowing your spinal cord. As always, you can find the aggregated posts in my totally new, fresh off the line category, neuroanatomy. There posts are organized in reverse chronological order, so the first post on the medullary pyramids would be at the bottom, which is where I recommend you start if you’re new. For everyone who’s followed along or those of you who are just interested in this one tract, let’s talk about the spinocerebellar tract!

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Day 165: Know your spinal cord – The rubrospinal tract

Art by Ramon y Cajal
Art by Ramon y Cajal

Drawing of a spinal cord slice by Ramon y Cajal, a Spanish neuroscientist and Nobel prize winner

This is day nine of know your spinal cord. Now for my usual bits, we have a whole category that I created just for these posts. They are in chronological order with the newest posts first, so I would recommend you start from the beginning post or dive in where you’re interested. That said, we’re going to tackle one of the smaller, but still important tracts, the rubrospinal tract!

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Day 164: Know your spinal cord – The grey matter

vintage spinal neurons

Drawing by Ramon y Cajal, a famous Spanish neuroscientist.

Today is day eight! I can hardly believe it, but here we are, day eight of spinal anatomy. For those of you who are just joining us, we have a whole new category just for these posts and they are in order from newest to oldest, so start at the bottom and work your way up. For those of you who have been following along, today we are tackling the grey matter of the spinal cord, a somewhat complex region where all the action takes place.

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Day 163: Know your spinal cord – The spinal nerves

Spinal cord

Here we are, a week into knowing your spinal cord (remember we have a new category for you to find these posts). If you’re just starting out, you may want to look at our new neuroanatomy category and start with the first post. For those of you who have been following along, we covered some of the major tracts of the spinal cord, so let’s dive into the structure some! First up, let’s talk about spinal nerves and what exactly these guys do.

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Day 162: Know your spinal cord – The spinothalamic tract

Antique engraving illustration: Spinal cord and brain

Day six already! Today is day six of knowing your spinal cord and we’re talking about the spinothalamic tract today. If you’re interested in the other posts, the first covers the medullary pyramids and I even have a category just for these posts. Of all the tracts of the spinal cord, this is probably my favorite becuase it is just so weird! You’ll see what I mean, so let’s get to it.

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Day 161: Know your spinal cord – The medial lemniscus tract

spinal drawing

Here we are day five of knowing your spinal cord. If you’re just joining us, I’ve created a new category where you can find all the posts. Or you can start at the beginning with the medullary pyramids (technically not part of the spine, but close enough). If you’re all caught up or just want to learn about this specific tract, then let’s get started.

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Day 160: Know your spinal cord – The corticospinal tract

spinal cord cross section drawing

We’ve made it to day four of knowing your spinal cord. I’ve introduced a new category just for this, which makes these posts easier to find for future reference (yours or mine). For those of you just starting out, you may want to go from the first post on the medullary pyramids. For the rest of you, you’re probably here to learn about the corticospinal tract. This will be fun, so let’s get started.

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Day 158: Know your spinal cord – The anatomy

leonardo da vinci spine drawing

Now that we took it from the top, let’s get an overview of what exactly makes up the spinal cord. There is a lot, so we’re not going to do a comprehensive review since that would be a whole class and not a single post. Most of the structures we cover today, will have a seperate post where we can go into detail.

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Day 157: Know your spinal cord – Medullary Pyramids

brainstem drawing

I’m excited that today we are starting the know your spinal cord series that I’ve been working on. Today we are going to take it from the top, no really. We’re starting at the top of the cord and we will work our way down. So without further delay, let’s look at the curious case of the medullary pyramids!

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