We're a little crazy, about science!

Posts tagged “daily routine

Day 303: Police food fight

steakshack

Well here’s something I never thought I would have to write about, the food is all right. Contrary to reports by police, no one is poisoning their food. In fact, every time a new story comes up regarding tapered food and the police it turns out the officers involved were (surprise!) lying outright. There are strangely so many of these incidents that it’s hard to keep up with, what is it about police that makes them think it’s okay to keep lying?

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Day 302: The supreme court weighs in and LGBTQ+ lives matter!

trans lives matter

Well as if we didn’t already have an overabundance of apocalyptic events occurring all at the same time, now we have trump rolling back protections for the LGBTQ+ community while the supreme court ruled in favor of protections for LGBTQ+ people. It’s all very confusing, but while we’re trying to burn down the system, need to build in protections for the LGBTQ+ community too.

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Day 301: We mourn the loss of a beloved… wendy’s

Wendy’s burns

Rayshard Brooks was murdered by police. Murdered isn’t quite a strong enough word for what the police did, but we’ll go with it. He was murdered. I don’t know the man, but I can tell you he had three daughters and a step son. I can also tell you he was murdered for being responsible. He was murdered for celebrating his daughters 8th birthday. He was murdered for doing the right thing. But today we mourn the wendy’s that was burned down.

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Day 300: Protest media blackout

Protests

The protests are still going strong and that makes my heart happy. You knew the protests were still going on though… right? I don’t blame you if you thought they had died down, turns out when protesters aren’t burning down buildings the media doesn’t seem to care, even when police decide to use excessive force and LITERALLY run people over.

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Day 299: Solid Modeling – Week 1

Full render

Welcome to solid modeling for beginners! Each week I’ll post some new and exciting things so you can try your hand at solid modeling. It’s easier than it looks to get started and once you do, you’ll be able to create amazing things that you can 3D print, plans to build something really cool, or maybe you just want to create some art! You can do anything you want with solid modeling, that’s the beauty of it! Let’s get started.

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Day 298: A slight delay

Delay

Well today I was planning on posting a quick tutorial for everyone who wanted to learn solid modeling. Have no fear! We’re still going to do it, but that will have to wait to tomorrow. I’ve got a lot going on at the moment and creating a good tutorial from scratch will take a bit of time. What am I doing now? Well, I’m glad you asked. 

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Day 262: A Brief Repose

Legion

A project from a few winters ago in my old home. My workshop was so organized!

A friend once described me as, “a maker if there ever was one.” If you ask me, he was being overly kind, but it’s true I enjoy making things. I’m always looking to learn new skills or sharpen old ones. In fact, I’m taking up some “light” woodworking over the summer to do some custom pieces for my home. It will be a fun task, if not a bit tedious and time consuming. I have a list of projects you see, but not a lot of time to do them.

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Day 261: On Being a Mentor

Tree

One of the many hats I wear as a PhD candidate is my mentor hat. It’s probably one of my favorite jobs and I get to work with some truly brilliant people from all types of backgrounds. I’ve had the chance to mentor a small handful of people and I always look forward to learning from them and through our interactions, in that sense, it’s a mutually beneficial relationship.

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Day 260: The thing about endings

The end

…and thus our mighty hero slay the beast and rode off into the sunset to live happily ever after. But why? Have you ever really thought about the way some stories choose their endings? Our hero goes through live altering and extremely daunting challenges only to brush it off like he caught the wrong bus. Pardon me, but what the actual fuck?

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Day 259: The Postscript

Sleep

After awhile you supposedly end up resembling your pet, I think it’s happened. She looks how I feel.

I just want to sleep for fifty years, is that so much to ask for? The deadline is gone whence it came! That does not mean it wasn’t a fight to the end or that there is a weird stillness permeating the house like a calm after a storm. What is it about things ending so abruptly that throws a person into a spiral of confusion?

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Day 226: Coronavirus and the military response

U.S.S. Theodore Roosevelt

U.S.S. Theodore Roosevelt

Well I got word yesterday that the coronavirus found its way onto an aircraft carrier. For anyone who’s never seen one in person, because the pictures don’t do it justice, these things are huge. Think floating cities with the crew size to match. Inside an aircraft carrier, there are roughly 3,000+ people who work, live, and maintain the ship. The one in question, the U.S.S. Theodore Roosevelt has over 4,000 crew members and those are just the ones that need to be quarantined. This is bad for a lot of reasons. For those of you who haven’t served in the military, I’ll explain.

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Day 225: Class presentations

Presentation

Presentation

For the past week we have been utilizing online resources so that classes can continue while we are all social distancing. While this is means that we mostly use Zoom, we also have message boards and other resources that we can use. However, these resources are sometimes a poor substitute for in person classes. This is especially apparent when we have certain assignments for the class, such as a group presentation.

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Day 224: Review – Cortical and Subcortical Effects of Transcutaneous Spinal Cord Stimulation

Figure 1 of the paper showing the experimental set-up and the type of pulse used for stimulation
Figure 1 of the paper showing the experimental set-up and the type of pulse used for stimulation

Experimental set-up. (A) Participants were comfortably seated in a customized chair during transcutaneous electrical spinal stimulation (TESS) or sham-TESS for 20 min. TESS was delivered using a surface electrode on the back of the neck between C5–C6 spinous processes segments (cathode) and a surface electrode in each anterior crest of the hip bone (anode) using a custom made 5 channel stimulator (BioStim5, Cozyma). Electrophysiological and behavioral outcomes were tested before (Pre) and immediately after, 15, 30, 45, 60 and 75 min after the end of the stimulation or sham stimulation period. (B) Schematic representation of the type of current used during TESS. We used 5 biphasic pulses at 5kHz with each biphasic pulse lasting for 200us. The middle scheme shows the blocks of 5 biphasic pulses passed at a 30Hz frequency. Lower part of the schematic shows the number of pulses delivered in one second.

Well it’s been two weeks since the last critical review so it’s that time again. As usual, my PI gets a copy and so do all of you. Since I’ve done several of these now (this is number six) I have a category just for these reviews called critical reviews. This is a really new study which tries to help tease apart what we are actually stimulating when we apply transcutaneous spinal stimulation. I think it’s a super interesting paper and I hope you do as well.

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The VA wants me dead, do you?

I swear I didn't kill anyone by the incredibly talented Lora Zombie.
I swear I didn't kill anyone by the incredibly talented Lora Zombie.

I swear I didn’t kill anyone by the incredibly talented Lora Zombie.

I hate writing about the VA, I really do. Unfortunately because I live here in the US where we think it’s our right to die from disease and have ludicrous amounts of medical debt for a sprained ankle, it’s a conversation we should have. Hello America, I served my country and now my country wants me dead. I sincerely wish I was exaggerating. Please hold your, “thank you for your service” for the end that way I can tell you to go fuck yourself. Let me explain…

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Day 216: So I’m “essential” now…

pandemic

Fun fact, I love pandemic movies. Movies, not so much living through one. As humans we are selfish, greedy, prone to panic, and for being “evolved” we are so very, very stupid. Basically every dumb choice you see the characters in those movies make while screaming, “you idiot, that would never happen in real life!” Well, it’s happening and wow does it do a number on a persons mental health. But hey guess what? I’m essential, so let’s figure out what that means in a time where the world is practically on fire.

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Day 215: What now?!

look ahead

Social distancing is important, but maybe not this distant…

Well if you missed it, yesterday was our final post in the know your spinal cord series. I’m not crying, you’re crying! Now the question is, what does that mean for the blog? An excellent question, one I wish I would’ve asked myself!  Let’s take a look at some of the things that we will (probably) be discussing now that our designated topic has run its course.

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Day 214: Know your spinal cord – The Recap

motor neuron histology

It’s day fifty-four and we’ve hit the end of our journey for this mini-series. For one last time, you can find all our posts in the neuroanatomy category. Everything comes to an end eventually and today I think we should do a small wrap up. This isn’t just a repeat of everything we went over though, we’re going to attempt to tie a lot of the topics together. So let’s give this a shot.

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Day 213: Know your spinal cord – Translating neural signals

whole brain and spinal cord dissected

whole brain and spinal cord dissected

Here we are on day fifty-three, we are nearing the end for sure. I was going to end the series today, but there is at least one more thing that I think will be interesting to cover. As always, you can find all of our posts in the neuroanatomy category, after all there are quite a few now. Today we are going to talk about how the brain and muscles use different signals to communicate. Basically, they speak different languages; let’s talk about what that means.

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Day 212: A small break

It was bound to happen, with the COVID-19 outbreak, my entire schedule has been shifting faster than I can keep up with it. I was going to force myself to write today, but I need a break. I’m exhausted both mentally and physically. There is a possibility I won’t be getting my stipend from the school this month, even though I’m still working, and I have assignments due soon, so I can’t dedicate the normal hour or so I would writing.

Friendly reminder, wash your hands, don’t touch your face, and practice social distancing. Even if you’re healthy, you can infect people that are not healthy or worse, people who work with others who are not healthy. Don’t be selfish! It may seem stupid now, but if we don’t do these things then it will get a lot worse and no one wants that. We can get through this if we all work together.


Day 211: Know your spinal cord – Transcutaneous spinal direct current stimulation

tsDSC simulation
tsDSC simulation

E amplitude distribution over the spinal cord and nerve surface. The color scale on the right is normalized with respect to the maximum of E amplitude in the spinal cord.

Well after our short break yesterday with my biweekly review paper, it’s back to the know your spinal cord series and we’re on day fifty-two! If you’re here for the first time, you can find the posts in this mini-series in the neuroanatomy category. We’ve taken a few twists and turns since we’ve started the series, but we’ve covered way more than I originally planned. We’ve covered how transcutaneous spinal cord stimulation is thought to work, that post focused on the type of spinal cord stimulation I’m researching. However, there are other ways to stimulate the cord. Transcutaneous spinal direct current stimulation (tsDCS) is a different way to stimulate and today we will talk about the difference.

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Day 210: Review – Cervical trans-spinal direct current stimulation: a modelling-experimental approach

Cervical trans-spinal direct current stimulation - Fig. 3
Cervical trans-spinal direct current stimulation - Fig. 3

Average magnitude of the E-field and average amplitude of its components in the spinal-WM in all montages along the z axis. Position of spinal segments is marked on the grey vertical bar, electrodes are represented by vertical bars and active connectors are marked with letter “A”. Volume plots of the E-field magnitude in cervico-thoracic spinal-WM, brainstem and cerebellum are represented at the right of the average distribution in each montage, with the corresponding colour scales

I lied! I did know what today was going to be on, it’s the fifth critical review paper. Since my PI gets a copy, so do you! To be honest, I need to create a category for these reviews (Update: I did make a category, Critical reviews), but for now, my first looking at elbow spinal stretch reflexes is here. My second where I review modulating spinal cord excitability with a static magnetic field here. The third where I review modulating the H-reflex while walking in spinal cord injury populations. Lastly, my fourth on Motoneuron excitability during voluntary muscle activity in a spinal cord injury population  can be found here. That said, let’s take a look at my latest review.

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Day 209: Know your spinal cord – Microglia

macrophage eating a bactria
macrophage eating a bactria

We cover this in the post, but it’s so cool I had to use it for the featured image.

It’s day fifty-one of knowing your spinal cord! For those of you who just found us, fear not we have all these posts in reverse chronological order listed in our neuroanatomy category. For everyone else, lately we’ve been talking about glial cells. This came about from the post on glial scarring which made me realize we should probably define glia. There are four types of glial cells found in the spinal cord (that we know of) we’ve covered three of them already and today we are talking about the last kind, the microglia.

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Day 208: Know your spinal cord – Ependymocytes

ependymal cells
ependymal cells

Ependymal cells, which create cerebral spinal fluid (CSF), line the ventricles of the brain and central canal of the spinal cord. These cells are cuboidal to columnar and have cilia and microvilli on their surfaces to circulate and absorb CSF.

We made it to yet another milestone, day fifty in our know your spinal cord series! As usual, you can find each and every one of these posts neatly organized in reverse chronological order using our neuroanatomy category. For the past couple of posts, we’ve introduced the types of glial cells, probably a bit poorly, but they are just so complex we can only really focus on a few of the functions. Needless to say they are very important cells. Today we are talking about the third (of four) types of glial cells found in the spinal cord (and brain), that is the ependymocyte. Let’s take a look.

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Day 207: Know your spinal cord – Astrocytes

upregulated spinal cord astrocytes
upregulated spinal cord astrocytes

SNL induces MCP-1 upregulation in spinal cord astrocytes (A–C)MCP-1 expression in the spinal cord of naïve animals (A) and SNL animals at 3 days (B) and 10 days (C). Scale bar, 200 μm. (D–F) High magnification images of (A–C), indicated in the white boxes of A–C, show the dorsal horn of the ipsilateral spinal cord. Scale bar, 100 μm. (G–I) Double staining shows that MCP-1 is colocalized with GFAP, a marker for astrocytes (G), but not with NeuN, a marker for neurons (H) or OX42, marker for microglia (I). Scale bar, 50 μm. DOI: 10.1523/JNEUROSCI.3623-08.2009

Day forty-nine in the spinal cord series! You can find all the posts in this series in our super useful neuroanatomy category. A couple of posts back we introduced glial scarring, one of the problems we need to overcome to help people with spinal cord injuries. That led to the realization that we needed to introduce the glial cells, so yesterday we covered the oligodendrocytes and today we are talking about the astrocyte. Now that we have some background of how we got here, let’s introduce today’s topic.

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