We're a little crazy, about science!

Posts tagged “science

The central limit theorem in statistics

Today we’re gonna push it to the limit! The central limit theorem that is. It’s a cornerstone in statistics and the short and dry version is that it lets us turn any distribution we have into a normal distribution. If it wasn’t for the central limit theorem statistics would hurt far worse than it does now (speaking as someone taking a stats class now). For the longer version we need to discuss why a normal distribution is needed, why we prefer to work with them!

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Effect size in statistics

Imagine our population data is the red curve and our sample data is the blue and the post will help you make sense of it.

We’ve been talking statistics for the past few days and today we’re talking effect size. The short explanation is effect size is the difference between two conditions! The bigger the effect size, the easier it is to tell the two conditions apart, easy… right? There’s a lot that goes into determining effect size, after all it’s hard to know what your effect size is without having some prior knowledge about what you’re groups look like, so let’s go into some detail.

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Errors in statistics

type 1 erro
type 1 erro

Everyone makes mistakes, that’s okay! In day to day life there are a lot of different ways you and I could make mistakes. In statistics however, there are just two ways for you to make a mistake. That may sound like a good deal, but trust me when I say two ways to make a mistake is two too many. To think, you spent all that time picking the right statistical test, did the experiment, analyzed the data, just to make an error in the end. Don’t worry, it happens to the best of us, but knowing what they are will help you prevent them!

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The hypothesis in statistics

As promised today we’re talking statistics for experiments! It’s more interesting than it sounds… okay it’s exactly as exciting as it sounds. Depending on who you are that’s a lot or not at all. No matter where on the spectrum you fall, knowing how it works is useful. So we’re starting at the beginning and discussing what a hypothesis is and how we test it.

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The last PhD requirement

Real photo of me determining significance between two samples. It’s scarier than it looks.

We’re already at the end of the month, how the hell did that happen? It’s been close to a month and a half since the term started and it feels like it’s flying by. I realized that when I first started this project I covered a lot of the stuff I was learning at the time. In fact one of my previous class notes posts was in my top 10 highest viewed blog posts for 2020. Somewhere along the line I stopped doing that, so today we’re going to talk about what I’m taking this term, why I’m taking it, and why I’ll probably be adding a few step by step instructions for how you can do what I’m learning too in some of my upcoming posts.

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A look ahead

With the weather trying to kill everyone, the pandemic trying to kill everyone, and just life in general I feel like things are moving…. slooooow. I have a weekly meeting with my main-PI who reminded me that I’m behind and while he agreed it was probably due in part to the pandemic, it’s time to try and catch up. There is a lot going externally and internally, but I’m hoping that by covering a few things here I will have a nice little list I can refer back on and keep me on track. That’s the idea anyway.

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What is good outreach?

Yet another outreach event in the books! I have two more events this week and I believe that’s the last for my skype a scientist commitment. Since this term I was assigned classes practically all at once, I may re-volunteer to get a few extra classes in this term. Normally requests for my specific field don’t happen, but they’ve become more frequent, which is interesting to see because biomedical engineering, or my subset neuroengineering, isn’t a widely known field, but it is growing. All this recent outreach has gotten me thinking about what makes a good presentation, so let’s talk about it.

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Outreach as a hobby

I reference this photo later in the post, but it’s my robot foot!

It feels like only yesterday I was fighting to stay alive and stay warm, but now like a bad dream it’s gone before it settled. Sure I’m still stiff from sleeping on the floor and the water isn’t on yet, but life has quickly thrown us back into “normal.” I don’t understand how people can shift so suddenly like the last week didn’t happen, but here we are, and here I am getting ready for another round of outreach.

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My scicomm video is done!!

I finally finished my video for the outreach project my main-PI tasked me with (this was the last post talking about it). There was a lot of time, effort, frustration, and I will admit, some not so kid appropriate language I was using during the editing process of the video. Mostly because I’m an idiot who had to find the most difficult way to do this project. Today we’ll cover what I did, how I hate myself enough to do it, and the end result. Let’s just say I’m not going to be a movie director or actor anytime soon…

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Paper submission!

This morning I woke up to some good news! I got an email letting me know that the journal paper I’ve been working on has been submitted. It’s not the end, it’s only the beginning really. It needs to be reviewed before we know the outcome, but I’ve spent the past ten months or so writing this damned thing, so this is a huge moment for me.

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Back to outreach

Just hanging out with the bots.

Today was the finish line, like it or not the R21 grant had to be finished. My Co-PI seems happy enough about the outcome, so we’ll have to wait and see what the result is, it could be several months before we know anything. It was a marathon of work, data process, experimenting, and now… nothing. I’m finally done so I can actually focus on other projects, which is the topic of the day!

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R21 Deadline

Today is the FINAL day for me draft before we send the R21 proposal off for internal review. Technically I think we have all day tomorrow too, but I need to get this back to my Co-PI for review and his final edits before we can submit it. The good news is the scientific writer was very thorough with their edits and suggestions, the bad news is I told my Co-PI I would get it back to him tonight before realizing how much there was to do!

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The zero factorial

Permutations and combinations and math, oh my!

Today I’m doing some stats homework and was reminded of an odd quark in math, the zero factorial. It’s not very intuitive and I absolutely love weird math, so I thought I would share the fun. I never said I was normal… Anyway today we’re going to go over why 0! (zero factorial) is so interesting!

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A clear path!

The easy path to getting your PhD…

That was quick! I have an update regarding yesterday’s funding debacle already… it’s good news, but that’s all the hint you’re getting for now! Things are happening fast and frankly they need to I only have a few more days to finish the grant before its due for internal review and I don’t know how my Co-PI is feeling right now, but I’m stressed out!

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Trouble on the horizon

I did not see this one coming… or maybe I did and just wanted to pretend it wasn’t going to be an issue. There’s been a difference of opinion to put it lightly. I received an email this morning from my main-PI asking if we could meet to discuss my funding options and he also casually mentioned that the R21 might not get submitted.

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Scientific figure design

Well I’ve done it… sort of. I edited the grant for the semi-last time. Now we’ve got a working copy that reads the way we want it to read, so it’s off to the scientific writer to read over it and make sure it sounds good. You would think that means my work is done, but no. I need to do arguably the hardest part and create some of the figures we will use in the paper. Writing well takes practice, but making a good figure, well that’s art.

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R21 Grant update

We’re not even two weeks aways away from the deadline for the grant submission that I’m working on with my Co-PI and things are getting close! It feels like there is still so much to do that I don’t see how we would ever make it to the end, but really a lot of it comes down to polishing everything to make it look pretty. Part of writing a grant is telling a story, that story needs to be backed up by science, but without the story the grant will fall flat.

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Book chapter update

It feels like it’s been a while since we talked explicitly about the book chapter I am writing. A lot has happened since that first post, mostly edits and what not. Since the second round of edits was due yesterday (and I hit that goal, thank you!) it won’t hurt to do a bit of a refresh and remind everyone why I took on yet another thing on my long list of to-do tasks.

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End of the month crunch

It’s the end of the month and that means there are a lot of loose ends I need to tie up before the new month begins. Deadlines I need to hit, plots to make, projects due, heck I even have a book chapter due. There’s just a lot going on and not a lot of time to finish it all. It seems to be a common theme that things are “due” at the end of the month for me. This month is no different, but with school having started, it gets a little more hectic than normal.

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Experiment Results

It’s been a crazy week, more so than usual! The R21 grant I’m writing is due to my Co-PI today, it’s our self imposed deadline. It’s not THE deadline, but it might as well be in my mind. I’ve processed most of the data from the experiments and yesterday I said we would talk about the result from finding an error in my code. Well let’s talk about it!

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To code is divine, to err is human

Yesterday we had a problem. My data was not playing nice. It decided that I didn’t really have what I thought I should be seeing and that left me… anxious to say the least. Since this is all so new, one misstep could ruin everything. To make things worse, there was one of three choices and none of them were good news.

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The last experiment!

Today’s the day! It’s the last experiment for our R21 grant, we had our first set of experiments last week and today we’re completing the final experiment today. Hopefully we’ll have some good results for our grant, I got done processing some data last night and if I didn’t make an error the results were slightly underwhelming, but we’ll have to see I guess. There’s still a lot of things I need to check so I’m not too worried, okay slightly (very) worried…

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Overloading in education

Get your PhD they said! It will be worth it they said. You’ll have a good time they said! They certainly say a lot don’t they? Well I say things shouldn’t be so freaking hard. I get that getting your PhD requires work and frankly, it should require work, I mean it’s a freaking PhD! That said, it shouldn’t be a four to six year gauntlet of torture to see how many times you break down mentally and physically. It doesn’t build character, or better PhD’s, but it is the system we work in.

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Make a SciComm video, the hardest way possible!

Writing, and filming, and edits… OH MY! I’ve done it, I’ve committed to making this science communication video (SciComm for short, if anyone was wondering about the title). Yesterday I went into the lab to do some filming and realized that I was about to make a great video, or at least I like to think so. But more importantly I was going to do it the hardest and most convoluted way possible. Why? Well, why the heck not?

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A new science outreach project

Today we’re making a movie! Okay, it’s not a movie persay, it’s a virtual outreach project I’ve been tasked with by my main-PI. Unlike most outreach I do, this is going to take some planning, a bit of script writing, a easy to do exercise that can be followed at home, and lastly a little write up on everything going on. So when I say some planning, I mean a LOT of planning!

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Experiments update!

Yes the data always look like a bunch of random squiggles, that’s why it takes forever to make sense of it.

Well a lot has happened this week, maybe not the most interesting of things for my readers, but this week has definitely kept me on my toes. Today we’re going to have to talk in circles because I can’t give away my “super secret” technique I’m researching, but I also have news about that technique. It’s all very hush, hush, top secret, would have to kill you if I told you type stuff for now, but that doesn’t mean we can’t talk about how the experiments I’m doing went!

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Second grant experiment

Data processing…. now in parallel!

Ever have one of those days that is so packed full of stuff to do you don’t think you’ll get a chance to eat? Well today is one of those days for me, I’ll be busy from morning to evening today between my experiment and class I don’t get a break! Since that’s the case, I think we should look at what’s on the agenda for the day in a bit more detail and how I plan on managing my time so that (hopefully) I won’t be late for anything.

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More on grant writing

Got the first round of edits back from my Co-PI on the R21 grant I’m writing. At first they didn’t look too bad, but it turns out he reworded quite a bit. Not that big of a deal honestly, but he did suggest that it was close to perfect, so I would hate to see what “not close” looks like. Today I figure we can discuss what I have left, why there’s a rush to get all this done, and why the heck I’m doing soooooo much writing!

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More experiments!

*Cue mad scientist laugh* It’s alive!!! ALLLLIIIIVVVEEE!! No, I’m not reanimating corpses, I just work with human participants so if they weren’t alive it would be awkward. I mean really, really awkward. Thankfully since they are non-invasive experiments the risk of serious injury is almost zero. All this build up to say I’ve got some new experiments starting today, as in MY experiments! *Cue second mad scientist laugh*

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The first week of classes

When you start a PhD program, or a Masters program (I have a BS and MS so I can speak to this) things aren’t as structured as they are in undergrad. Not that undergrad programs aren’t hard or not hectic, it’s just that there are scheduled times for everything so you know when and where you will have work. It’s a lot like highschool in that respect, you get homework, but there’s a clear end to it. Not so much in grad school, your homework takes a year or even years (for a PhD) to finish. Still, it’s the first week of school, so things change, if only slightly.

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Everything you should know about the COVID vaccine

I’ve already written several posts on my experience with the first COVID vaccine dose (here and here) and the second dose (here and here). Today we’re putting it all together. I’m going to run through everything you should know about the COVID vaccine from how it works, to why you should get it, and what to expect when you go through the shots. My goal with this is to make it accessible as possible so you can make an informed decision and feel comfortable getting the shot. Sometimes the science is hard to understand, but I think we can simplify it enough to make sense to just about everyone. That said let’s give it… a shot.

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COVID Vaccine: The second shot update!

Well today is a full day since I had the second dose of my COVID vaccine. I promised honesty and transparency so here it is, the second dose isn’t as smooth as the first. So we’re going to go over why that is, what my issues have been, and why it’s still very much worth it.

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COVID Vaccine: The second shot

We’re talking spike proteins, the thing that gives COVID-19 its distinct look (red spikes).

Today is the day! It’s been roughly two weeks (if I’m counting that right) since I got my first COVID-19 vaccine shot and today I’m getting my booster, or second shot, whatever we’re calling it. For that reason, today we’re going to recap the last two weeks and discuss what may happen with the second shot. It’s not as exciting as it sounds, but there’s a lot of misinformation out there so it’s important to document all this.

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I’m going into surgery… sort of!

Okay well this came out of left field, or rather happened faster than I thought it would. My Co-PI and I had discussed just last week seeing some of how the more clinical stuff gets done in terms of electrophysiology and invasive monitoring. He suggested I shadow some of the doctors while they are performing surgery to see how they do the things they do and now I’m about to get the chance to do just that. Yeah, that’s a lot of doing.

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A day of meetings and emails

Okay, my inbox isn’t that bad, but if I didn’t keep up with it, it could easily get there.

It’s a new day with a new and long list of things I need to get done. I’ve already got a ton of bad news about my car issues and the rather large bill that is coming with that, but I’ve also got meeting after meeting scheduled for today on top of a long, long list of emails that need responses from me. Basically today is going to be exhausting and all I will have done is sit in front of a computer, how the hell does that even work?!

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First grant meeting

Time to put the fun in funding?

Well it’s been a weird couple of days and by weird I mean, WTF?! For that reason let’s shift slightly back into the school aspect of things. I had my first meeting with my Co-PI to discuss the grant writing I’m going to be doing and what we want to focus on. Turns out there’s a lot going on and not all of it had to do with the grant, but it was a good meeting and I’m excited to get started.

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New year, new grant

It’s all connected somehow… I just know it.

Nope, still on vacation… I tell myself as I make arrangements to meet with my Co-PI. This is important though and unlike some of the other projects it has a firm deadline. That’s right, I’m writing a grant. No this isn’t an update to the last one I wrote, this is a whole new one. How did I end up in this position? Who knows, but I’ve been trying to figure it out since it happened. Let’s discuss, shall we?

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I’m getting my COVID vaccine today!

Today is the day! About a week ago I got an email letting me know that I could be vaccinated. While I’m a researcher in a hospital, my work involves a high risk population (people with spinal cord injury) so I’m front facing with patients on a regular basis. I’m also disabled which may have factored into my group placement. Whatever the case, I got a spot in line and now it’s my turn. My Co-PI who’s lab I work out of already got his, but he was in a higher group than I was. As usual I have some thoughts on all this…

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The perils of publishing

So you want to publish some science. I don’t blame you, as a scientist we’re driven by the “publish or perish” mindset. The further along you get the more you’re stuck having weird nightmares about h-index and impact factor. Or maybe that’s just me, who knows? In any case, any publication is a labor of love, one that typically turns into a labor of spite. Because publishing isn’t easy, or maybe that’s just me.

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Outreach

I just finished with my Skype a Scientist session! You can do it too if you want, just sign up. I had a lot of fun and while today was going to be on a slightly more depressing topic, I figure we can talk about how it went instead. I love doing outreach, it’s probably one of my favorite things about being a scientist and I got to show a whole bunch of interesting things I get to do as a scientist. This was an interesting group, so that’s also a good reason to talk about it.

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Please, stay home for the holidays!

Don’t do it. Seriously, why are we having this discussion right now? It makes no sense, there is a pandemic going on and if you live specifically in the US (which I do) you’re going to need to stay home. Sure the holidays can be an important time of year for families, but do we really need a holiday to celebrate with our family? Why not wait until this is over? More importantly is it worth putting all of them, yourself, and the people you come in contact with at risk?

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And finally something good…

I don’t know why my mind went with hidden treasure, but that’s what we’re going with today.

It was bound to happen eventually, some good news for today! I had a meeting with my Co-PI and we went over the latest findings in the dataset I’m processing for my “super secret” technique and I have to say it went much better than was expected! He’s excited, I’m excited, we’re excited. The issue is we don’t know what any of it means, but I think that’s why it’s so exciting!!!!

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Outreach in a pandemic

I’ve been matched! No, not with a dating service, with an outreach program called Skype a Scientist. If you are a scientist (any type will do) you can get involved too! I’ve talked about some of my outreach activities in the past, but heck let’s run through why I think outreach is so awesome and how the pandemic has actually made it easier to do!

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A change in my timing

The meeting with my PI is done and it’s not all bad news. It went better than expected in some aspects and not so great in others. That’s how these things work out, it’s not a linear progression, it’s a lot of going back and forth and sometimes side to side too. Thankfully we met before I made any firm plans! Anywho, let’s just dive in and talk about what happened.

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More data, more problems

Maybe the title should be no data, no cry. Anyway here we are another day and there’s a lot going on, but I finally did it! I got some results from my new dataset that I hadn’t had a chance to process yet. And would you believe (despite the title) that I found something!? Yep, which is great news… except there’s more I need to do! My Co-PI who likes to temper my excitement when I come to him with results has reminded me that I should wait to celebrate until the rest of the data are analyzed.

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A meeting with my PI

It’s a treacherous path, but one I need to take

Well I may have overestimated how fast I could get the data processed from yesterday. I have it basically done, but I was up until almost 2am getting it to that point and I didn’t have the energy to start the analysis so that’s going to happen today. Instead of sharing my excitement for a second day in a row I thought I would share some news. I got an email back from my PI and tomorrow we are meeting.

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An early present

Since my deadline has come and gone I can look around for a moment, but more importantly I don’t feel the pressure to hyperfocus on a single project. So today instead of working on that dataset I’m switching to a dataset I need to get done before my PhD proposal defense. It’s data that will (assuming I find something) further help make my case for studying my new “super secret” technique for the next 2-3 years depending on how long everything takes.

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A mental health day

Today the fatigue of the past few weeks has finally caught up to me. With the adrenaline rush that came to a head from the presentation I did yesterday wearing off, I feel exhausted. So today I am taking some time to recharge and rethink what the next few months will look like. This is me taking a mental health day, but let’s talk about the events leading up to today and what the plan is, at least for today.

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How to fail giving a presentation

Today is the big day! The day where I showcase the stuff I’ve done. It’s a bit anticlimactic to be honest because I haven’t had time to do a full analysis, just a very general overview. It was COVID you see, we shut down for a few months there so I didn’t get any data collected. When we finally got started again I had weeks to do the analysis, not months. Needless to say it’s not good.

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The science behind an MRI

Today I had an MRI, don’t worry it was for research purposes. It wasn’t a short MRI either, I was in the bore for almost two hours. Yep, stuck in a tube with nothing but my thoughts, some music, and the sounds of the MRI machine doing its thing. I figure we can discuss what an MRI is, why I had one, and why I don’t mind that it took so long. I may even show off some of the scans, but not today I don’t have them yet.

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