We're a little crazy, about science!

Archive for 2021

New year’s eve!!

It’s that time again. We’re bringing in another year. Let’s be real, the last two years have been progressively worse and 2022 doesn’t look like it will start off any better. I don’t know what will be in store for us in the upcoming year, but my one request to anyone who stumbles upon this is to be kind to each other. Wear a mask, get vaccinated, then boosted, and if we can finally work together, maybe we can at least make 2022 the year we beat COVID. I’m not optimistic, but I’m happy to be proven wrong. To each and every one of the readers of my little blog, happy new year to you and yours. And thank you for spending another year with me on my journey.


Books read in 2021

With the end of the year upon us, I figure it’s time to commit to my books read in 2021 list. Last year I believe I did something similar, if not, I should have. In any case, every year as part of my “lazy goals” I challenge myself to read a certain number of books. The purpose is to stop and relax from time to time. Or just to carve out a couple of hours to enjoy reading a good story, well hopefully good. Want to read something, but aren’t sure what? Don’t worry, I have some recommendations!

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New year, new experiments

We are an alarming number of days away from the new year. Where did this year go? Why did it suck so bad? Why was this possibly the best year we will see in our lifetimes? Why am I asking so many damned questions? Am I having an existential crisis now that the year is coming to an end? That was a legit question and not part of the running gag. I’m a man who likes his plans, so let’s look at what (I hope) is instore for next year.

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Another OR experiment

Time to dust off my scrubs, it’s back to work for me. In fact, I have been so busy with other things I don’t think I mentioned it, but today is yet another OR experiment. With how well the previous two went, I’m hopeful that this one will go well, but a somewhat alarming email from hospital-PI yesterday may throw a wrench into any plans I had.

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Salted caramel apple empanadas

Technically this is a failure and from a previous batch, but I love that you can see the filling inside

Fine, I will give out my recipe! But be warned with great empanadas come great responsibilities! In other words, once you make these for your friends or family you’ll be obligated to make more. Ask me how I know! That said, I never bothered to write down the recipe, I’ve always made it by “feel,” but since I’ve shared pictures twice now of the result I keep getting the request for it.

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A marathon of cooking

How it all started… (remember cut veggies/fruit before meats to avoid cross contamination and ideally use separate cutting boards)

Well it’s been an interesting few days. Since I don’t get to have a traditional holiday experience (due to COVID), like most people I know, I opted to make enough food to feed a small army so I could share some with basically everyone in a safer manner than having one big celebration. Over the past two days I’ve spent a total of 18 hours in the kitchen, but who’s counting? Me, I’m counting.

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Happy holidays!

Well, it’s Christmas day again and we are still dealing with COVID. Maybe you’re numb to it or maybe you’re like me and incredibly stressed out about it. Whatever the case this year probably looks very different from prior years and even from last year. Last year I wished that COVID would be a history lesson and not a current event. Maybe it was ambitious, but I don’t want to lose hope so once again my holiday wish is that next year we beat this and can properly mourn for those who were lost during this (ideally) brief period of history. So from my “crazy” little family to yours, happy holidays!


‘Tis the season!

Well I wish I could say that today is a regularly scheduled day of relaxing. In a way it kind of is? Today is my regularly scheduled prep for tomorrow’s dinner. Now I don’t have a traditional family, but I do have friends and what not, so I’m making a rather large meal. The plan (as it is every year) is to have plenty of leftovers for myself, but also to have enough to hand out to friends and coworkers when Monday rolls around.

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The year I met Alice

Not quite that Alice, but I definitely felt mad afterward.

Every year around this time I think of Alice (not her real name). Alice and I have a lot in common. We have the same last name, same initials, and we had no idea the other existed until one day when I randomly checked my email and discovered a serious case of mistaken identity. That was my introduction to Alice, so every year I think about her and wonder how she’s doing. But my dear reader, the story isn’t about the emails. The story is about what happened next.

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OR experiments, the aftermath

The good news is we have data! Lots of data, more data than you could shake a stick at, although I don’t know why you would shake a stick at anything… That’s beside the point(ed stick) though! Yesterday was not one, but two OR experiments and I have to say surgeon-PI must be in way better shape than he appears because both hospital-PI and I are exhausted!

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Interrogation of spinal networks during movement preparation using transcutaneous spinal stimulation

Rundown of the experiment (A) shows where we stimulated and what muscles we recorded from. (B) is our experimental protocol that we used. We had an auditory cue, a tactile cue (a small electrical stimulation of the foot, which causes a slight tickle) and an isometric contraction task. (C) has examples of what the evoked potentials look like and it can be hard to read at first, but the far right has a very clear example (R1 is our first stimulus and R2 is the second). I don’t go into why we used 2 pulses, but there is a reason, it’s just a bit technical so outside the scope of this general review.

That’s not the name of the paper, but that’s the general idea. We tend to take movement for granted, I mean most of the time we do it without thinking. I don’t look down as I’m typing these words, yet my fingers know what to do to make it happen. Similarly, we don’t really think about balancing ourselves when we walk, we just do it. So if I’m not consciously thinking about every step I take when I walk down the street, who, or what is keeping me going?

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Yet another rush…

It’s a familiar story by now. Tomorrow is not one, but two experiments in the OR. In fact, I’m going to be so busy tomorrow that I’m probably going to write tomorrow’s post today. The good (or at least interesting) news there is that I have a good topic lined up for tomorrow since it just happened to fall in my lap. But for today, well let’s just say there’s not a whole lot of time.

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Holiday magic, a how to guide!

Well it’s the holiday season. Whether you’ve already celebrated, are about to celebrate, or don’t celebrate at all, one thing is certain. Things look a whole lot different than just a few years ago. I, of all people, understand feeling numb or helpless as we look around us and see all the suffering that is going on. I can also acknowledge that if we’re going to get through this then some self care is in order. For a lot of us, even if we’re not the religious type, the holidays are supposed to be magical. So it’s my annual reminder that with a little effort you can help bring a little magic, or maybe a bit of mischief to the season.

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End of the year blues

As the year wraps up, I still feel like there’s quite a bit of work left for me to accomplish. Now to be fair, year end isn’t some magical barrier, but it is a good way to mark the passage of time and I’ve had the opportunity to do some amazing things this year, so I’m not complaining. Still, with all the accomplishments I’ve had, and there were several, why do I feel like I have so much left to do?

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The path moving forward

Pick your battles. After having a conversation with another student about their PhD plans and how soon they want to graduate, they offered that sometimes you need to pick your battles. I couldn’t agree more with that statement and when I met with school-PI a few days ago virtually to go over my big PhD plans I asked what I needed to do to finish. I needed to pick my battles.

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Double OR experiments!

It’s official, I just got not one, but two new participants for our study. This will be happening next week and the scary part is they are both on the same day, so it will be more than a full day in the OR, like 12 hours or so for the whole day. Not all of that time will be spent in the OR, thankfully. Every attempt we’ve had thus far in the OR has gotten better and better, so if the pattern holds, we should have some very good data after this next round of participants and I will have more data than I know what to do with.

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Success! Journal paper 2 of 4

Well kids, Christmas has come early! As of this morning my second of four journal papers I’ve written has been accepted for publication! Since it’s been a somewhat long and confusing road, I figure today I can remind everyone why I’m so thrilled about this paper and why this is good news for me in particular. There’s still a lot to do and more papers to publish as we go, but things are looking up!

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The fifth OR experiment

Well we did it. I finally have the first (mostly) complete dataset from a patient. Overall I think it went well and we got good data. Mistakes were made! But thankfully none of them derailed the project and overall I am happy with the outcome. Let’s get into what went wrong and what went right, because having some post surgical notes will help me next time we do our thing.

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Prepping for the experiment

Today’s the day, experiment number five. With lot of luck this will be the first full experiment we do for this protocol. It will hopefully mark a turning point for us since after four attempts we’ve yet to get a full dataset. However, I’m hopeful, but I’m also going in alone today.

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Solo OR experiment

Tomorrow will mark attempt number six to get the data we’re after from the OR. We’ve got a very unwieldy experiment to do which involves coordinating with the surgeon, but also the staff to make sure we don’t run into each other. It’s a delicate dance and if you haven’t been following along, it hasn’t been great so far.

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A not so certain future

I have a lot of health problems. If I were to dedicate a post to each we would be here awhile. They affect me in ways that I’m very aware of and sometimes I’m left to wonder if they affect me in ways I don’t always notice. Maybe my communication skills are just that awful or somehow my brain just can’t make sense of things. I feel like I’m going crazy, but it has to be me… right?

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Paper three resubmission!

This was quick even by my standards, but we’ve managed to make the changes we needed to the manuscript that came back just a few short days ago (here). I’ve got to come up with a more descriptive way to talk about these papers than numbering the order in which we did them, but that’s what I’ve been using for the moment. In any case the paper has been submitted, so what now?!

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A big idea…

You ever have an idea that you just KNEW would change the way you were doing things. Like the first person to invent a surgical robot, it was just a good idea and it completely changed the way things were done. I don’t think that this idea is going to change things that dramatically, but much like my super secret technique, I think my recent revelation is going to mean some great things for me. Lighting struck the other day and it has hospital-PI incredibly excited.

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Journal Paper three update!

Well that was fast, we got reviews back on a paper we recently submitted and they were surprisingly good for us. It’s still considered major revisions, but they gave us ten days to make the changes. Ten days as of Monday, so were about a week away from needing to resubmit. There’s some work to be done for sure, but I think we can manage.

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Fun with collaborators!

So much has been going on that I can’t even keep up with it. I was debating about what news to share, but I think we’ll talk about something I’ve had in the works for awhile now. Actually I just checked my email exchanges, this has been in the works for over a year and today we finally crossed the threshold from hypothetical to real world data collection!

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Update from the OR

I don’t share actual surgery photos online (even if I could, I don’t know that I would), but there are plenty stock photos, like this one!

No, I’m not updating this while I’m in the OR, but we had OR attempt number five as a maybe today and I have good news. We managed to get a yes at the last minute and got some interesting data. It’s all very exciting, so now I need to dig around and see what we found. For sake of remembering, let’s run through how today went!

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The art of fixing things

Me right now.

Well today has been one hell of a day. It’s a long story and we’ll get into it, but I had to once again do some car repairs. It got me thinking about others who may not have the skill to do that or other things that feel very necessary for living, but I’ve had a hard life and so you have to learn the skills that others may not have needed.

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Another OR experiment… maybe

I got a random email yesterday from hospital-PI that I didn’t understand and I’m still trying to figure out what’s going on, but it looks like experiment number five may be happening as early as Monday! It will be an early morning and a long day, but it will be worth it, assuming it happens. Like everything in my life at the moment, we’re not 100% sure that we will be able to attend.

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The BIG result

Art by: Rebecca Wright

Today I had my meeting with school-PI and I have to say it went both better and worse than I was hoping for. The good news is I’m still a member of his lab and he seemed surprisingly okay with me switching projects for my dissertation, not that the project would change much, just the funding source. Of course that doesn’t mean it was all sunshine and rainbows, because that would be too easy.

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The BIG meeting

I am a simple man. I keep my life as simple as possible because some days I can barely get out of bed. Breakfast and lunch have been the same things for years and I’m okay with that, in fact dare I say, I look forward to it? I keep my hair cut short so I don’t have to even think about it and besides the things I need like money to live, I don’t go out of my way to complicate things. Aside from my education and the things related, I have very little that I NEED to do, so I can focus on surviving the day. It’s a good system.

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To catch an error

Well it’s been an adventure! First we collected some one of a kind OR data, then because of technical difficulties couldn’t get it to open. The support team for the software has been amazingly responsive and we were able to recover the file! Or so we thought, saving the file caused the error to reoccur, so we needed more help. Thankfully because we could open the file, I could debug and now I look like a data wizard. So this is the story of how I attacked and dethroned the data gods.

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The last experiment

Goodbyes are hard, even if you don’t really know someone outside of work. Today we’re saying goodbye to a few of our participants as they finish one of our longer experiments. It feels like only yesterday, but it’s been several months now so it’s time to wrap things up. The good news is this will create a bit of an opening in my routine, but that’s probably going to be filled in pretty quickly.

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The tough conversations

One of the things I left (intentionally) off my to-do list for the week post was the talk with school-PI about hospital-PI. The plan is to arrange the meeting sometime either this week or next depending on school-PI’s availability to have the talk. I’m not thrilled about it and I don’t know how this will turn out, but it has to happen and it has to happen soon.

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Technology issues…

I’ve quickly come to regret purchasing my new(ish) fancy laptop. I get complements on it because it looks impressive and if it worked correctly it would be very impressive. The problem is that it has been causing me headaches since I bought it. Technically this is the second one, the first one was replaced and the second had the same exact issues. So instead of exchanging it again and going through that whole mess, I decided to crack it open and do the fixing myself.

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The week ahead

Semi-regularly I like to look forward at the things I want to accomplish in the next week. Having a good plan going forward helps me focus on the things that need to get done and the literal act of checking things off my list is literally the only thing that keeps me going some days. As usual I’m juggling a lot, but thanks to my 365 days of academia project, I’ve realized this, which means we can adapt… hopefully.

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A day off

Well today nothing serious is going to happen. I have no plans, no work I need to do (urgently anyway) and I could use some time to unwind. Today seems as good a day as any to take the time for myself and thus I have nothing to write about. Breaks are important, in fact, take this as a chance to take a break for yourself. Go do something you enjoy, or not. Your choice. The thing about self care is it’s whatever works for you.


Thanksgiving 2021

Well it’s thanksgiving. As usual for anyone who’s picked up a history book, celebrating thanksgiving is one hell of a choice. Granted it was made generations ago so we do it out of habit and I am happy to have the extra time off, although time off as a student is more of a concept and not an actual thing. Point being, celebrating genocide is something we do here in the US. Because that’s how we were founded.

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Dear data gods

We have offered our typical sacrifice of blood, sweat, and some might even say excessive amounts of tears. Yet clearly we have offended you and we are not sure how or why. We ask that you forgive our ignorance and help us understand how we can fix this. We are humbled and sorry, we should not seek higher truths, yet we must continue.

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Mad dash to the OR

Today has been a day! The trick with doing research in the OR is that the schedule for the surgeries don’t get finalized until the day before and sometimes even then things change at the last minute. I’m not sure when the schedule was finalized or if anything changed, but this morning I got a text that threw everything out of order. The best laid plans of mice and men…

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Writing rush

Well today I will be spending the bulk of my time editing a journal paper that needs some work. Okay a lot of work, it’s not great, but I feel like it’s a case of switching fields. Something I know all too well when I jumped from mechanical engineering to neuroengineering. I try to be polite when editing because it’s stressful enough as it is. However, it’s important to remember that it’s the paper being critiqued, not you.

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The fourth OR experiment

It’s official! We have experiment number four coming in two days. I’m excited about another attempt to collect data and to answer about a dozen interesting questions since we just keep tacking on stuff to look at when we go in. I’m not even joking, the experiment list keeps growing because the opportunity is unique and they don’t add significant amounts of time to the main experiment we’re doing.

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Another year of NDSEG

Yesterday was the last day to apply for the NDSEG fellowship and if the traffic to my fellowship tips post (here) is any indication about the number of people who applied, this year is going to be competitive. It’s bittersweet for me, because this is the first year I won’t be applying. Mostly because I am no longer eligible for it, but also because I literally have more funding than I know what to do with.

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End of the week rush

It’s Friday, which means I need to be at both the hospital lab and the school lab. Then it’s wall to wall meetings with little break in between. How am I writing this if I’m so pressed for time? Well I have a second between meetings and things I need to do. It’s busy, but the good news is I’m forced to focus on the stuff right in front of me, which is better than having to focus on other things that are going on at least.

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Into the storm

Yep, things are looking gloomy around here. Did I mention I hate this time of the year? It feels like everything conspires to go wrong around this time of year and it just happens to be when my depression and anxiety are cranked up to 11 pretty much all day every day. I don’t enjoy it and I wish I could just hide until the new year rolls around and the feeling passes, but here we are another year where I am super anxious and another year where everything seems to be going wrong.

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The garden of forking paths

It’s called the butterfly effect and goes something like, “a butterfly can flap its wings and cause a hurricane on the other side of the world.” That’s not exactly true, like most things it’s an easy way to remember the concept. Something small can have a ripple effect that you may not be able to anticipate. In other words, chaos. The problem is chaos, the universe is not deterministic so predicting the future, even the immediate future, comes with a certain level of uncertainty. It’s only in hindsight can we trace back certain events and see the pattern and even then depending on the scale, it’s impossible to know which butterfly caused the hurricane or if the flapping of a butterfly’s wings prevented one.

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Sometimes things get cancelled

Today was a big day. We got the equipment ready, the patient consented, and everyone on the clinical side of things was on the same page we were on. Things were going well. Surprisingly well in fact, that should’ve been the first sign something was going to go wrong. This time it wasn’t our fault though! Sometimes you just can’t catch a break, so maybe next time.

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Off to the OR!

Tomorrow is the big day, our second experiment and while I’m a little nervous, I’m also excited to see what we can do. Last time around we had some issues… okay a lot of issues, but that’s because it was the first time we’ve ever tried something like this. This time around we worked with the team that will be in the OR with us so we know what they are doing and this time they know what we are doing. Basically we’re aiming for a whole lot less drama and a whole lot more useable data, meaning any usable data!

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DIY Research

When I say arts and crafts projects, I really do mean there is art involved.

Working in a big fancy hospital research lab means I get access to all sorts of very expensive, very cool equipment that I wouldn’t be able to use normally. Things that I take great pains not to break because, well… it’s not cheap. If we need something, we order it and the process is surprisingly fast considering the amount of paperwork that goes into placing an order. However, on occasion there are no ready pieces of equipment that I can just use for an experiment or we don’t know that the big expensive piece of equipment that we’re looking at is the thing we actually need. So what other options do we have? Spoiler, it’s arts and crafts time.

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Experiments from the OR

The last place you would expect to see me doing non-invasive research would be the operating room. Surgery, even the minor stuff, can be very invasive, but that doesn’t mean we can’t collaborate and combine our techniques. Of course this is the first time anyone in the hospital has tried to collaborate like this (that we know of anyway) so there’s bound to be some growing pains. Luckily we’re about to go into our second real attempt at this and I think we’ve worked out all the problems.

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Presentations in a pandemic

Today was the first in person presentation I’ve done in years. Literally years thanks to the pandemic. I’ve been avoiding large gatherings and will continue to do so, but this was a special case since it was a hospital event. We’re all vaccinated, masks were required, and we were distanced in a well ventilated area, so it was the first time I’ve really felt comfortable attending an event like that. Before we get into the talk, let me just say it feels weird wearing dress clothes for the first time in years. I don’t know that I mind the sweatpants lifestyle so much (okay I definitely don’t mind it), but it was fun to mix it up a bit and shave, which I also stopped doing since the pandemic because, why not?

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